NFKB1
NFKB1，即核因子kappa B亞基1，別名p50，它是核因子-κB（NF-κB）/Rel蛋白家族的一員。NFKB1基因位于3號(hào)染色體上，編碼的p50蛋白通常與p65（RelA）形成異二聚體，參與多種生物學(xué)過程，包括先天和適應(yīng)性免疫、炎癥、應(yīng)激反應(yīng)、B細(xì)胞發(fā)育和淋巴器官形成。在細(xì)胞質(zhì)中，NF-κB與IκB蛋白結(jié)合并受到其抑制。當(dāng)細(xì)胞受到炎癥因子、脂多糖（LPS）、生長(zhǎng)因子等刺激時(shí)，IKK復(fù)合體激活，導(dǎo)致IκB磷酸化和降解，釋放NF-κB/Rel復(fù)合體?；钚訬F-κB/Rel復(fù)合體進(jìn)一步激活，并轉(zhuǎn)運(yùn)入細(xì)胞核，誘導(dǎo)靶標(biāo)基因表達(dá)。NFKB1在調(diào)節(jié)免疫反應(yīng)和炎癥過程中發(fā)揮關(guān)鍵作用，其異常激活與多種疾病的發(fā)生發(fā)展有關(guān)，包括自身免疫疾病、炎癥性疾病和某些類型的癌癥，是藥物開發(fā)的重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) (CSB-EP015759HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Phospho-NFKB1 (Ser932) Antibody (CSB-PA142672)
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from 293 cells untreated or treated with TNF-a using NFkB-p105(Phospho-Ser932) Antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105(Phospho-Ser932) Antibody(left) or the same antibody preincubated with blocking peptide(right).
Human Nuclear factor-kappa B,NF-κB ELISA Kit (CSB-E12107h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E12107h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NFKB1 Antibodies
NFKB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA10354A0Rb | NFKB1 Antibody | Human | ELISA, WB, IHC, IF, ChIP |
| CSB-PA10354B0Rb | NFKB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10354C0Rb | NFKB1 Antibody, FITC conjugated | Human | |
| CSB-PA10354D0Rb | NFKB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA015759GA01HU | NFKB1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA142672 | Phospho-NFKB1 (Ser932) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA283590 | Phospho-NFKB1 (Ser927) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA186775 | NFKB1 (Ab-337) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA108426 | NFKB1 (Ab-893) Antibody | Human | ELISA,WB,IHC |
| CSB-PA696291 | NFKB1 (Ab-907) Antibody | Human | ELISA,WB,IHC |
| CSB-PA190132 | NFKB1 (Ab-932) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA632717 | Phospho-NFKB1 (Ser337) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA258273 | Phospho-NFKB1 (Ser893) Antibody | Human | ELISA,IHC,IF |
| CSB-PA925652 | Phospho-NFKB1 (Ser907) Antibody | Human | ELISA,WB,IHC |
| CSB-PA000579 | Phospho-NFKB1 (S893) Antibody | Human | WB, IHC, ELISA |
| CSB-PA000580 | Phospho-NFKB1 (S907) Antibody | Human | WB, IHC, IP, ELISA |
| CSB-PA000581 | Phospho-NFKB1 (S932) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA000683 | Phospho-NFKB1 (S337) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA000730 | Phospho-NFKB1 (S927) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA003430 | NFKB1 Antibody | Human | WB, IHC, IP, ELISA |
| CSB-PA003431 | NFKB1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA003434 | NFKB1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA004763 | NFKB1 Antibody | Human | WB, ELISA |
| CSB-PA020084 | Phospho-NFKB1 (S337) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020085 | NFKB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020086 | NFKB1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA020090 | NFKB1 Antibody | Human | WB, IHC, ELISA |
| CSB-PA020096 | NFKB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA259078 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA546304 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA441503 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,WB |
NFKB1 Proteins
NFKB1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015759CH CSB-EP015759CH CSB-BP015759CH CSB-MP015759CH CSB-EP015759CH-B |
Recombinant Chicken Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015759HU1 CSB-BP015759HU1 CSB-MP015759HU1 CSB-EP015759HU1-B |
Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP103544h | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) | E.coli |
| CSB-EP015759HU | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) | E.coli |
| CSB-EP015759HU1 | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | E.coli |
NFKB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015759MO CSB-BP015759MO CSB-MP015759MO CSB-EP015759MO-B |
Recombinant Mouse Nuclear factor NF-kappa-B p105 subunit (Nfkb1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723572RA CSB-EP723572RA CSB-BP723572RA CSB-MP723572RA CSB-EP723572RA-B |
Recombinant Rat Nuclear factor NF-kappa-B p105 subunit (Nfkb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP739094DO CSB-EP739094DO CSB-BP739094DO CSB-MP739094DO CSB-EP739094DO-B |
Recombinant Dog Nuclear factor NF-kappa-B p105 subunit (NFKB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 ELISA Kit
NFKB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12107h | Human Nuclear factor-kappa B,NF-κB ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
NFKB1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12108m | Mouse Nuclear factor-kappa B,NF-κB ELISA Kit | serum, plasma, cell culture supernates | 0.078 ng/mL |
NFKB1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13148r | Rat Nuclear factor-kappa B(NF-κB) ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/ml |
