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  4. Rat Nuclear factor-kappa B(NF-κB) ELISA Kit

Rat Nuclear factor-kappa B(NF-κB) ELISA Kit

  • 中文名稱：
    大鼠核因子κB(NF-κB)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13148r
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.56 pg/ml-100 pg/ml
  • 靈敏度：
    0.39 pg/ml
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠核因子κB(NF-κB)酶聯(lián)免疫試劑盒（CSB-E13148r）為雙抗夾心法ELISA試劑盒，定量檢測樣本中的NFKB1含量。NFKB1基因編碼NF-κB 蛋白復(fù)合物的p50亞基，在免疫反應(yīng)、細胞增殖、凋亡等生理過程中起著關(guān)鍵作用。研究機制主要聚焦于其激活通路及下游靶基因調(diào)控，異常激活與炎癥、腫瘤等疾病密切相關(guān)，是藥物研發(fā)的重要靶點?？蓾M足科研場景下對炎癥信號通路激活程度的動態(tài)監(jiān)測、免疫相關(guān)疾病動物模型的機制探究，以及藥物干預(yù)實驗中NF-κB活性變化的定量評估需求，為分子生物學(xué)和藥理學(xué)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Nfkb1 ELISA Kit; Nuclear factor NF-kappa-B p105 subunit ELISA Kit; DNA-binding factor KBF1 ELISA Kit; EBP-1 ELISA Kit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] ELISA Kit; Fragment ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 反應(yīng)時間：
    1-5h
  • 上樣量：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
     
  • 線性度：
     
  • 回收率：
     
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

相關(guān)問答

■ 常見問題解答
Q:

How can I convert pyggrams per decilitre to picograms per milligram, because your kits are in deciliters and concentrates
picogeram/dl---picogeram/mg
this kits according to picogerm/dl, i want according to picogeram /mg

A:
Thanks for your inquiry. For the kit indicated,convertions are not suggested.We recommand you caculate according to the unit stated in the manual.
Pls let me know if you have any further questions. Thank you.

靶點詳情

  • 最新研究進展：
    NFKB1是一種轉(zhuǎn)錄因子，能夠介導(dǎo)炎癥、免疫反應(yīng)、細胞生長和凋亡等多種生物學(xué)過程。最新的研究發(fā)現(xiàn)，NFKB1在人類疾病的發(fā)生和發(fā)展中發(fā)揮著重要作用。例如，研究人員發(fā)現(xiàn)NFKB1在腫瘤的發(fā)生和轉(zhuǎn)移中發(fā)揮了重要作用，并且抑制NFKB1的活性可以抑制腫瘤的生長。此外，NFKB1也參與了許多自身免疫性疾病的發(fā)生和發(fā)展，如類風(fēng)濕性關(guān)節(jié)炎和炎癥性腸病等。
  • 功能：
    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. Isoform 5, isoform 6 and isoform 7 act as inhibitors of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm. Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
  • 亞細胞定位：
    Nucleus. Cytoplasm.
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