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  4. TNFRSF25 (SL-325 Biosimilar) Recombinant Monoclonal Antibody

TNFRSF25 (SL-325 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839000MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    TNFRSF25(SL-325 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物制劑，其靶點為腫瘤壞死因子受體超家族成員25（TNFRSF25），該受體在免疫調節(jié)、細胞凋亡及炎癥反應中發(fā)揮關鍵作用。本產(chǎn)品通過基因工程技術制備，采用重組表達系統(tǒng)獲得高純度、高特異性的單克隆抗體，為免疫學、腫瘤學及炎癥相關領域的基礎研究和藥物開發(fā)提供有力工具。 該抗體具有高度的靶向結合能力，可特異性識別并結合TNFRSF25受體，通過阻斷或激活受體信號通路，深入探究其在免疫細胞活化、自身免疫性疾病發(fā)病機制及腫瘤微環(huán)境調控中的功能。產(chǎn)品經(jīng)過嚴格的質量控制，確保批次間的穩(wěn)定性和一致性，適用于及體外細胞功能實驗等多種研究場景。 在科研應用中，TNFRSF25重組單克隆抗體可助力揭示受體介導的信號轉導機制，為理解免疫穩(wěn)態(tài)維持、炎癥性疾病進展及腫瘤免疫逃逸等過程提供重要實驗依據(jù)。其高親和力和低交叉反應性特點，能夠有效降低非特異性結合干擾，提升實驗結果的可靠性與準確性，是生命科學研究領域中探索TNFRSF25生物學功能的理想工具。 本產(chǎn)品僅供科研使用，不用于臨床診斷或治療，建議在專業(yè)實驗人員指導下按照標準操作規(guī)程進行操作，以確保實驗安全與數(shù)據(jù)有效性。
  • Uniprot No.：
  • 基因名：
  • 別名：
    SL325 research-grade biosimilar; SL 325 research-grade biosimilar ;TNFRSF25 antibody; APO3 antibody; DDR3 antibody; DR3 antibody; TNFRSF12 antibody; WSL antibody; WSL1 antibody; UNQ455/PRO779 antibody; Tumor necrosis factor receptor superfamily member 25 antibody; Apo-3 antibody; Apoptosis-inducing receptor AIR antibody; Apoptosis-mediating receptor DR3 antibody; Apoptosis-mediating receptor TRAMP antibody; Death receptor 3 antibody; Lymphocyte-associated receptor of death antibody; LARD antibody; Protein WSL antibody; Protein WSL-1 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TNFRSF25 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
  • 基因功能參考文獻：
    1. Hypermethylation of the proapoptotic genes BCL2 L11 and TNFRSF25 is observed in pleomorphic adenoma of the salivary glands. However, this phenomenon did not impact mRNA transcription. PMID: 28941993
    2. the DR3/TL1A pathway directly enhances human OC formation and resorptive activity, controlling expression and activation of CCL3 and MMP-9. PMID: 28062298
    3. Untreated children with IBD have higher percentage of DR3(+) PBMCs. PMID: 27001939
    4. In addition to apoptosis, DR3 can robustly trigger necroptotic cell death and provide evidence for TL1A-induced, DR3-mediated necrosome assembly. DR3-mediated necroptosis critically depends on receptor-interacting protein 1 (RIP1) and RIP3, the core components of the necroptotic machinery, which activate the pseudo-kinase mixed lineage kinase domain-like, the prototypic downstream effector molecule of necroptosis. PMID: 27592300
    5. Data suggest that human regulatory T-lymphocytes express DR3 and demonstrate DR3/TL1A-mediated activation of signaling via MAP kinases and NFkappaB. (DR3 = death receptor 3; TL1A/TNFSF15 = tumor necrosis factor [ligand] superfamily, member 15) PMID: 28337757
    6. These results raise the possibility for involvement of TL1A/DR3/DR3-mediated mechanisms in epithelial-mesenchymal interactions and the development of inflammation-induced intestinal fibrosis in Crohn's disease. PMID: 27665176
    7. Activation of DR3 is accompanied by inhibition of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis. PMID: 27682848
    8. Biologics beyond TNF-alpha inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders. PMID: 26810853
    9. Higher DR3 levels were associated with early stage chronic lymphocytic leukemia. PMID: 26393680
    10. DR3 is efficiently activated by soluble TL1A trimers. PMID: 26509650
    11. These data identify new roles for DR3 in regulating OB-dependent bone mineral apposition. PMID: 26065008
    12. Human memory IL-18Ralpha and DR3 CD4+ T cells may contribute to antigen-independent innate responses at barrier surfaces. PMID: 25269704
    13. DR3 is expressed by IL-22-producing human group 3 innate lymphoid cells (ILC3s). PMID: 26046454
    14. These results suggested that TL1A could promote Th17 differentiation in rheumatoid arthritis via the activation of RORc, and this effect may be mediated by the binding of TL1A with DR3. PMID: 24832108
    15. Silencing of the DR3 gene affect levels of apoptosis antigen3 ligand in cells. PMID: 25370568
    16. DR3 is expressed in some interstitial vascular endothelial cells in human kidney in situ. These EC also respond to TL1A by activating NF-kappaB. Very low levels of DR3 are seen on the cell surface of HUVEC, which do not respond to TL1A. PMID: 25399326
    17. The changes in frequency of occurrence of spliced variants of DR3/LARD mRNA were directed towards modulation of apoptosis and restraint of antiviral immune response. PMID: 25929035
    18. Distinctions in occurrence of spectrums of DR3/LARD mRNA at healthy volunteers and colon cancer patients can define a different susceptibility of immunocompetent and tumor cells for apoptosis PMID: 25509355
    19. DR-3 drives early cartilage destruction in the antigen-induced model of inflammatory arthritis through the release of CXCL1, maximizing neutrophil recruitment to the joint and leading to enhanced local production of cartilage-destroying enzymes. PMID: 25044706
    20. Suggest tectochrysin leads to apoptotic cell death in NSCLC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation. PMID: 25083589
    21. TRAMP mice fed with 3'-diindolylmethane-supplemented diet show much lower incidence of tumorigenesis and metastasis than the untreated control group. PMID: 23658110
    22. Collectively, these data suggest a complex role for DR3 in breast cancer development and progression PMID: 23443464
    23. Both TNFRSF25 and TNFRSF4 independently and additively costimulate vaccine-induced CD8+ T cell proliferation following both primary and secondary antigen challenge. PMID: 22956587
    24. Protein expression of tumour necrosis factor (TNF)-like ligand 1A (TL1A) and death-domain receptor (DR)3 is upregulated in the aged bladder tissues. PMID: 22641456
    25. Investigated further the mechanisms by which the E-selectin-activated pathways downstream of DR3 confer a survival advantage to colon cancer cells. PMID: 21722370
    26. It was shown that IL-32 enhanced the cytotoxic effect of natural killer cells on protate cancer cells through activation of DR3 and caspase-3. PMID: 22043900
    27. in active psoriasis, we observed abundant immunostaining for TL1A and significant upregulation of its receptors DR3 and DcR3 PMID: 21672030
    28. role of TNFRSF25:TNFSF15 in disease and health PMID: 21153333
    29. critically involved in the pathogenesis of rheumatoid arthritis PMID: 20125169
    30. These data confirm that silencer of death domains (SODD) and death receptor 3 (DR3) are expressed in a regulated manner during renal transplant rejection, and identify DR3 as a potential inducible mediator of tubular inflammation and injury. PMID: 12875962
    31. TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis PMID: 12882979
    32. Death receptor 3 gene duplication is associated with rheumatoid arthritis PMID: 15241467
    33. TL1A and DR3 is involved in atherosclerosis via the induction of pro-inflammatory cytokines/chemokines PMID: 15760679
    34. VEGI gene expression is subject to regulation by inflammatory cytokines. VEGI is also able to regulate the expression of several important genes involved in angiogenesis. PMID: 16517446
    35. Results suggest that death receptor-3 activation can mediate apoptosis in osteoblasts, although its activity is highly restricted by its soluble ligand-binding isoform and possibly also by alternate survival signals. PMID: 16986165
    36. These results suggest that caspase-10, DR-3 and IGFBP-3 are involved in apoptosis in the preeclamptic placenta. PMID: 17085968
    37. TNFR25/TL1A pair provides an early signal for cytokine production in the lung, and therefore may be a drug target in attempts to attenuate lung inflammation in asthmatics. PMID: 18411341
    38. HLA-B8 and DR3 haplotype is associated with graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy PMID: 19674013

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  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.; [Isoform 10]: Secreted.; [Isoform 12]: Secreted.
  • 組織特異性：
    Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11910

    OMIM: 603366

    KEGG: hsa:8718

    UniGene: Hs.462529



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