TNFRSF25
TNFRSF25，全稱(chēng)為T(mén)umor Necrosis Factor Receptor Superfamily Member 25，別名包括DR3、LARD、APO-3等。該蛋白屬于腫瘤壞死因子受體超家族，主要表達(dá)于富含淋巴細(xì)胞的組織中，可能在調(diào)節(jié)淋巴細(xì)胞穩(wěn)態(tài)中發(fā)揮重要作用。TNFRSF25蛋白能與TNFSF12/APO3L/TWEAK結(jié)合，并直接與接頭蛋白TRADD相互作用，進(jìn)而激活NF-kappa-B信號(hào)通路，誘導(dǎo)細(xì)胞凋亡。此外，TNFRSF25蛋白還與BAG4蛋白相互作用，參與多種細(xì)胞反應(yīng)。目前，針對(duì)TNFRSF25蛋白的藥物研發(fā)主要集中在抗體類(lèi)藥物上，例如SL-325是一種First-in-Class抗體，屬于TNFRSF25拮抗劑，目前處于臨床前研究階段，用于治療炎癥性腸疾病。此外，還有多項(xiàng)關(guān)于抗TNFRSF25抗體的專(zhuān)利申請(qǐng)和研究報(bào)道，這些研究旨在開(kāi)發(fā)更有效的治療藥物，用于治療炎癥性腸疾病、自身免疫性疾病等。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF25 at 2 μg/ml can bind Anti-TNFRSF25 recombinant antibody(CSB-RA839000MA2HU). The EC50 is 4.485-5.277 ng/mL.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human TNFRSF25 at 2 μg/ml can bind Human TNFSF15(CSB-MP023992HU1c9). The EC50 is 13.26-15.80 ng/mL.
TNFRSF25 Antibody (CSB-PA004866)
驗(yàn)證數(shù)據(jù)
Western Blot analysis of K562 cells using DR3 Polyclonal Antibody
Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25) ELISA kit (CSB-EL023980HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL023980HU
規(guī)格：96T/48T
靈敏度：0.06 ng/mL
檢測(cè)范圍：0.24 ng/mL-15 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TNFRSF25 Antibodies
TNFRSF25 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA004866 | TNFRSF25 Antibody | Human | WB, ELISA |
| CSB-PA213899 | TNFRSF25 Antibody | Human | ELISA,IHC |
| CSB-PA839000LA01HU | TNFRSF25 Antibody | Human | ELISA, WB |
| CSB-PA839000LB01HU | TNFRSF25 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA839000LC01HU | TNFRSF25 Antibody, FITC conjugated | Human | |
| CSB-PA839000LD01HU | TNFRSF25 Antibody, Biotin conjugated | Human | ELISA |
TNFRSF25 Proteins
TNFRSF25 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-BP839000HU CSB-EP839000HU-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP839000HU | Recombinant Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25), partial | E.coli |
| CSB-YP839000HU | Recombinant Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25), partial | Yeast |
| CSB-MP839000HU | Recombinant Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25), partial | Mammalian cell |
| CSB-MP839000HUn6 | Recombinant Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25), partial (Active) | Mammalian cell |
TNFRSF25 ELISA Kit
TNFRSF25 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL023980HU | Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25) ELISA kit | serum, plasma, tissue homogenates | 0.06 ng/mL |
