LRRC15（Samrotamab Biosimilar Antibody）重組單克隆抗體是一種針對(duì)富含亮氨酸重復(fù)序列蛋白15（LRRC15）。LRRC15又被稱為β-淀粉樣蛋白誘導(dǎo)的富含亮氨酸重復(fù)蛋白同源物、hLib或LIB，是一種在多種組織中表達(dá)的跨膜蛋白，其結(jié)構(gòu)特征為胞外區(qū)含有多個(gè)亮氨酸重復(fù)序列，參與細(xì)胞黏附、信號(hào)轉(zhuǎn)導(dǎo)等生物學(xué)過(guò)程。該抗體以重組人LRRC15蛋白制備，具有高度的特異性和親和力，可特異性識(shí)別并結(jié)合LRRC15分子。 Samrotamab因其靶向的LRRC15在多種實(shí)體瘤（如乳腺癌、肺癌、胰腺癌等）的腫瘤微環(huán)境中高表達(dá)，成為潛在的治療藥物。目前研究聚焦于Samrotamab在腫瘤治療中的應(yīng)用，包括單藥治療或與化療、免疫檢查點(diǎn)抑制劑聯(lián)合使用，旨在通過(guò)靶向LRRC15抑制腫瘤基質(zhì)形成、減少腫瘤侵襲和轉(zhuǎn)移，或增強(qiáng)免疫細(xì)胞對(duì)腫瘤細(xì)胞的殺傷作用。此外，LRRC15在纖維化疾病中的表達(dá)異常也提示Samrotamab可能成為相關(guān)疾病的治療藥物，但臨床研究尚處于早期階段。 LRRC15重組單克隆抗體可用于多種實(shí)驗(yàn)體系。由于其對(duì)人、食蟹猴和小鼠均具有反應(yīng)性，適用于跨物種的基礎(chǔ)研究，包括實(shí)驗(yàn)，助力研究者分析LRRC15在正常組織和疾病模型中的表達(dá)模式、亞細(xì)胞定位及功能機(jī)制。例如，在腫瘤模型中，通過(guò)該抗體可研究LRRC15對(duì)腫瘤微環(huán)境中基質(zhì)細(xì)胞（如成纖維細(xì)胞）的調(diào)控作用；在纖維化模型中，可探討其在細(xì)胞外基質(zhì)沉積中的分子機(jī)制，為疾病的診斷和治療策略開發(fā)提供實(shí)驗(yàn)基礎(chǔ)。

Q8TF66

Leucine-rich repeat-containing protein 15；Leucine-rich repeat protein induced by beta-amyloid homolog；hLib , LRRC15, LIB

Human

Recombinant Human LRRC15 protein

Homo sapiens (Human)

Non-conjugated

Monoclonal

It differs from different batches. Please contact us to confirm it.

0.01M PBS，pH7.4

Liquid

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

In stock

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.