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  4. LILRB4 (BND-35 Biosimilar) Recombinant Monoclonal Antibody

LILRB4 (BND-35 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA850914MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LILRB4(BND-35 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開(kāi)發(fā)的生物試劑，可特異性識(shí)別并結(jié)合LILRB4（白細(xì)胞免疫球蛋白樣受體B4）蛋白。該抗體通過(guò)重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞中表達(dá)，具有高純度、高親和力和高特異性的特點(diǎn)，適用于多種實(shí)驗(yàn)場(chǎng)景。 LILRB4作為免疫球蛋白超家族成員，在免疫調(diào)節(jié)、炎癥反應(yīng)及腫瘤微環(huán)境調(diào)控中發(fā)揮重要作用。本產(chǎn)品為科研人員提供了可靠的研究工具，可用于某些實(shí)驗(yàn)，助力深入探究LILRB4的生物學(xué)功能及其在疾病發(fā)生發(fā)展中的機(jī)制。 該抗體經(jīng)過(guò)嚴(yán)格的質(zhì)量控制，包括蛋白純度檢測(cè)、結(jié)合活性驗(yàn)證及交叉反應(yīng)性測(cè)試，確保實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性。其穩(wěn)定的理化性質(zhì)使其適合長(zhǎng)期儲(chǔ)存，且在多種實(shí)驗(yàn)條件下均能保持良好的結(jié)合活性。 通過(guò)使用LILRB4重組單克隆抗體，研究人員可進(jìn)一步揭示免疫檢查點(diǎn)分子的調(diào)控網(wǎng)絡(luò)，為免疫相關(guān)疾病的機(jī)制研究和潛在治療靶點(diǎn)發(fā)現(xiàn)提供有力支持。該產(chǎn)品僅用于實(shí)驗(yàn)室研究，不應(yīng)用于臨床診斷或治療用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BND35 research-grade biosimilar; BND 35 research-grade biosimilar ;LILRB4 antibody; ILT3 antibody; LIR5 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody; B4 antibody; CD85 antigen-like family member K antibody; Immunoglobulin-like transcript 3 antibody; ILT-3 antibody; Leukocyte immunoglobulin-like receptor 5 antibody; LIR-5 antibody; Monocyte inhibitory receptor HM18 antibody; CD antigen CD85k antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 基因功能參考文獻(xiàn)：
    1. Results suggest that ILT3 played an important role in tumor progression in colorectal cancer by possible influence on CD45RO+ T cells in the tumor microenvironment. PMID: 30126665
    2. These results suggest that tyrosine phosphorylation may be critical in FcgammaRI-dependent endocytosis/phagocytosis that may be regulated by LILRB4 by triggering dephosphorylation of key signalling proteins. PMID: 27725776
    3. ILT3 may functionally contribute to a regulatory network controlling tumor progression by suppressing the Akt pathway. PMID: 28931525
    4. The ILT3 PBs/PCs were suggested to be developmentally equivalent based on the simultaneous generation of these populations upon activation of memory B cells in vitro ILT3 expression was found to be induced efficiently by IL-2, while IFN-alpha effectively induced ILT3 PBs/PCs in vitro Utilizing the elevated ILT3 will support opening a new avenue for molecular markers for, pathogenic cells. PMID: 27742834
    5. this study shows that LILRB4 might have dual inhibitory and activating functions, depending on the position of the functional tyrosine residues in its immunoreceptor tyrosine-based inhibitory motifs and/or the nature of the stimuli PMID: 28409541
    6. LILRB4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    7. Identification of ILT4 as a cellular receptor for CSP C4d PMID: 26678451
    8. ILT3Fc inhibits T cell activation and induces the generation of suppressor T cells targeting multiple inflammatory miRNA pathways. PMID: 22387553
    9. Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance. PMID: 21454581
    10. Data show that LILRB4 is a potent inhibitor of monocyte activation via FcgammaRI. PMID: 19833736
    11. ILT3 precursor RNA is expressed and retained in nuclei of resting endothelial cells. PMID: 16433759
    12. Our findings indicate that expression of ILT3 and ILT4 on CLL B cells represents a phenotypic abnormality that may play a role in tolerization of tumor-specific T cells. PMID: 17266150
    13. The inhibitory effect of serum and membrane ILT3 in a humanized SCID mouse model describes an immune-escape mechanism that could contribute to impaired T cell responses in patients with cancer. PMID: 17513794
    14. Both membrane and soluble ILT3 are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer. PMID: 17923119
    15. describe an immune-escape mechanism mediated by the inhibitory receptor immunoglobulin-like transcript 3 (ILT3) which may be responsible for failure of pancreatic cancer therapy PMID: 17993722
    16. Progenitor mast cells expressed cell surface inhibitory LILRB4. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface. PMID: 17998301
    17. ILT3-Fc is a potent immunoregulatory agent that suppresses islet allograft rejection in humanized NOD/SCID mice. PMID: 18420485
    18. 15 single nucleotide polymorphisms are identified in the extracellular domain of immunoglobulin-like transcript 3 gene from healthy individuals. PMID: 18486764
    19. Expressed on cultured osteoclast precursor cells derived from peripheral blood monocytes; could be inhibitory for osteoclast development in presence of receptor activator of NF-kappaB ligand (RANKL) and macrophage colony stimulating factor (M-CSF). PMID: 18802077
    20. A significant association is observed between ILT3 dendritic cells in kidney transplants and donor age. PMID: 19010139
    21. ILT3 may play a critical role in the control of inflammation. PMID: 19380766
    22. A tryptophan-deprived environment generates monocyte-derived dendritic cells with a marked up-regulation of inhibitory receptors ILT3 and ILT4 and enhanced capacity to induce CD4+CD25+Foxp3+ regulatory T cells in an ILT3-dependent manner. PMID: 19535644

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.
  • 組織特異性：
    Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6608

    OMIM: 604821

    KEGG: hsa:11006

    STRING: 9606.ENSP00000270452

    UniGene: Hs.67846



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