LILRB4

LILRB4（白細胞免疫球蛋白樣受體B4）是一種免疫檢查點分子，屬于白細胞免疫球蛋白樣受體家族B亞家族成員。它由胞外免疫球蛋白樣結構域、一個跨膜結構域以及含有免疫受體酪氨酸抑制基序（ITIMs）的細胞質(zhì)結構域組成。LILRB4在多種免疫細胞上表達，包括單核細胞、巨噬細胞、肥大細胞、B細胞、自然殺傷細胞、T細胞和樹突細胞等，具有調(diào)控免疫細胞活性、促進腫瘤免疫逃逸的功能。LILRB4通過與配體如整合素αvβ3結合，抑制肥大細胞活化，并通過其胞質(zhì)結構域中的ITIMs傳遞抑制信號，抑制免疫細胞活性。此外，LILRB4還可能通過招募SHP1來抑制NF-κB信號通路，這在動脈粥樣硬化的發(fā)生中可能起抑制作用。LILRB4的表達和功能在不同疾病中具有重要意義，尤其是在癌癥治療中，靶向LILRB4的抗體可能有助于抑制腫瘤免疫逃逸，提高免疫治療的效果。因此，LILRB4是免疫治療研究中的一個潛在靶點，其結構和功能的研究有助于開發(fā)新的治療策略。

熱銷產(chǎn)品

LILRB4 Antibody (CSB-PA850914ESR2HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: A549 whole cell lysate(30μg), MCF-7 whole cell lysate(30μg)
All lanes: LILRB4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa
Exposure time: 120s

LILRB4 Antibody

LILRB4 Protein

LILRB4 ELISA Kit

LILRB4 Antibodies

LILRB4 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA297929	LILRB4 Antibody	Human	ELISA,IF
CSB-PA006757	LILRB4 Antibody	Human	IF, ELISA
CSB-PA850914ESR1HU	LILRB4 Antibody	Human	ELISA, WB
CSB-PA850914ESR2HU	LILRB4 Antibody	Human	ELISA, WB

LILRB4 Proteins

LILRB4 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP731041MO CSB-EP731041MO CSB-BP731041MO CSB-MP731041MO CSB-EP731041MO-B	Recombinant Mouse Leukocyte immunoglobulin-like receptor subfamily B member 4 (Lilrb4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LILRB4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP850914HU CSB-EP850914HU CSB-BP850914HU CSB-MP850914HU CSB-EP850914HU-B	Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LILRB4 ELISA Kit

LILRB4 ELISA Kit for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	樣本類型	靈敏度
CSB-E11812h	Human leukocyte immunoglobulin-like receptor subfamily B member 4,LILRB4 ELISA Kit	serum, plasma, cell culture supernates, cell lysates	7.81 pg/mL