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  4. KLRG1 (Ulviprubart Biosimilar) Recombinant Monoclonal Antibody

KLRG1 (Ulviprubart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA846610MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    KLRG1 (Ulviprubart Biosimilar) 重組抗體是一種用于科研領(lǐng)域的重組單克隆抗體。該抗體針對(duì)KLRG1（殺傷細(xì)胞凝集素樣受體G1）靶點(diǎn)設(shè)計(jì)，通過(guò)重組DNA技術(shù)在體外表達(dá)制備，具有高度的特異性和均一性。 KLRG1作為一種跨膜蛋白，主要表達(dá)于自然殺傷（NK）細(xì)胞、部分T細(xì)胞亞群等免疫細(xì)胞表面，在免疫調(diào)節(jié)、細(xì)胞活化及腫瘤免疫逃逸等生物學(xué)過(guò)程中發(fā)揮重要作用。該抗體可特異性識(shí)別并結(jié)合KLRG1分子，為研究其生物學(xué)功能提供關(guān)鍵工具。 在科研應(yīng)用中，該抗體可用于某些實(shí)驗(yàn)，助力解析KLRG1在免疫細(xì)胞發(fā)育、分化及疾病發(fā)生發(fā)展中的作用機(jī)制。通過(guò)特異性阻斷或檢測(cè)KLRG1的表達(dá)與活性，研究者能深入探索其在自身免疫性疾病、腫瘤免疫治療及感染性疾病等領(lǐng)域的潛在研究?jī)r(jià)值。 該重組單克隆抗體制備過(guò)程嚴(yán)格遵循質(zhì)量控制標(biāo)準(zhǔn)，確保批次間的穩(wěn)定性和實(shí)驗(yàn)結(jié)果的可靠性，為相關(guān)領(lǐng)域的基礎(chǔ)研究和藥物靶點(diǎn)發(fā)現(xiàn)提供有力支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ABC008 research-grade biosimilar; ABC 008 research-grade biosimilar; ABC-008 research-grade biosimilar ;KLRG1 antibody; CLEC15A antibody; MAFA antibody; MAFAL antibody; Killer cell lectin-like receptor subfamily G member 1 antibody; C-type lectin domain family 15 member A antibody; ITIM-containing receptor MAFA-L antibody; MAFA-like receptor antibody; Mast cell function-associated antigen antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human KLRG1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • 基因功能參考文獻(xiàn)：
    1. KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment PMID: 27557510
    2. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase PMID: 27566818
    3. The results suggest that a disease-associated SNP located within the 3'UTR of KLRG1 directly interferes with miR-584-5p binding, allowing for KLRG1 mRNA differential accumulation, which in turn may contribute to pathogenesis of pemphigus. PMID: 27424220
    4. Demonstrate the presence of increased KLRG1-expressing T-cells in tuberculosis-treated individuals, and present KLRG1 as a marker of decreased human T-cell proliferation following BCG-vaccination. PMID: 26750180
    5. This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. PMID: 26014037
    6. high levels of TfRs such as those found on activated lymphocytes were found to be associated with decreased KLRG1 inhibitory function, indicating that TfRs may sequester KLRG1 from interacting with cadherins. PMID: 24752778
    7. More T cells were KLRG1+ in the synovial fluid of patients with spondylarthritis/rheumatoid arthritis than crystal arthritis or controls. Those T cells were more functionally active, and migrated towards the synovial fluid of SpA/RA patients. PMID: 23740233
    8. KLRG1 was overexpressed on CD4(+) T cells. PMID: 24337749
    9. Data indicate that increments of CD8 + effector memory T cells in human and mouse chronic lymphocytic leukemia (CLL)(Emu-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset. PMID: 24022692
    10. These results indicate that KLRG1 negatively regulates natural killer cell numbers and functions via the Akt pathway, thus providing a novel marker and therapeutic target for hepatitis C virus infection. PMID: 23966413
    11. The lower inhibitory capacity of mKLRG1 compared with hKLRG1 can thus be rationalized by a decreased proportion of dimeric entities, which can be pinpointed to a single amino acid. PMID: 22684915
    12. cytomegalovirus positive had lower proportions of NK-cells expressing inhibitory receptors (KLRG1 and CD158a) PMID: 21933704
    13. trastuzumab-mediated antibody-dependent cellular cytotoxicity was markedly enhanced by KLRG1-negative peripheral blood mononuclear cells PMID: 21387286
    14. Results demonstrated a substantial reduction in both CD94- and KLRG1- expressing CD3(-)CD56(+) NK cells with increased age. PMID: 20394788
    15. Expression of MafA analyzed in conditional knockout mice during embryonic development is the first specific marker of a subpopulation of "early c-ret" positive sensory neurons. PMID: 20213756
    16. human effector and memory T cells expressing KLRG1 lack proliferative capacity PMID: 12393723
    17. KLRG1 expression discriminated between cord blood T cells that differed in their post-thymic expansion rate PMID: 15368283
    18. KLRG1 is expressed in the overwhelming majority of CD8-positive T cells specific for epitopes of cytomegalovirus or Epstein- Barr virus during the latent stage; a slightly lower KLRG1 expression level is observed in HIV-specific T8 cells. PMID: 15879103
    19. virus-specific CD8+ T cells are mostly KLRG1+ in chronic viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus) PMID: 16140789
    20. peripheral HCV-specific CD8+ T cells were CD127+ and KLRG1-; Intrahepatic virus-specific CD8+ T cells displayed significantly reduced levels of CD127 expression but similar levels of KLRG1 expression compared to the peripheral blood. PMID: 17079288
    21. study demonstrates that E-cadherin represents a ligand for KLRG1 and that ligation of KLRG1 by E-cadherin inhibited effector cell functions of polyclonal NK cells PMID: 17617594
    22. Certain aspects of the dysfunction seen in highly differentiated CD8+ T cells are maintained actively by KLRG1 signaling. KLRG1 blockade enhances Akt (ser(473)) phosphorylation & T-cell-receptor-induced proliferation of CD8+CD28-CD27- T cells. PMID: 19406987
    23. E-cadherin may coengage KLRG1 and alpha(E)beta(7) and that KLRG1 overcomes its exceptionally weak affinity for cadherins through multipoint attachment to target cells, resulting in inhibitory signaling. PMID: 19604491

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6380

    OMIM: 604874

    KEGG: hsa:10219

    STRING: 9606.ENSP00000349477

    UniGene: Hs.558446



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