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  4. KARS1 (ZMA-001 Biosimilar) Recombinant Monoclonal Antibody

KARS1 (ZMA-001 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA618973MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    KARS1（ZMA-001 Biosimilar Antibody)重組單克隆抗體是一款專(zhuān)為科研用途開(kāi)發(fā)的生物試劑。該產(chǎn)品通過(guò)重組DNA技術(shù)制備，具有高特異性和高親和力，可精準(zhǔn)識(shí)別并結(jié)合靶標(biāo)分子，為生命科學(xué)研究提供可靠工具。 該抗體采用先進(jìn)的哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)生產(chǎn)，經(jīng)過(guò)嚴(yán)格的純化工藝和質(zhì)量控制，確保產(chǎn)品批次間的穩(wěn)定性和一致性。其高純度特性可有效減少非特異性結(jié)合，提升實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性，適用于等多種實(shí)驗(yàn)方法。 在科研應(yīng)用中，KARS1（ZMA-001 Biosimilar Antibody)重組單克隆抗體可助力研究人員深入探索相關(guān)分子機(jī)制、信號(hào)通路及疾病模型。無(wú)論是基礎(chǔ)研究還是藥物靶點(diǎn)發(fā)現(xiàn)，該抗體都能為實(shí)驗(yàn)提供有力支持，幫助科研人員獲得可靠的實(shí)驗(yàn)數(shù)據(jù)，推動(dòng)生命科學(xué)領(lǐng)域的研究進(jìn)展。 產(chǎn)品使用前需按照說(shuō)明書(shū)進(jìn)行適當(dāng)稀釋和處理，建議在-20℃條件下保存，避免反復(fù)凍融以保證活性。作為科研級(jí)試劑，其質(zhì)量符合嚴(yán)格的行業(yè)標(biāo)準(zhǔn)，為科研工作者提供穩(wěn)定高效的實(shí)驗(yàn)材料。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ZMA001 research-grade biosimilar; ZMA 001 research-grade biosimilar ;KARS1 antibody; KARS antibody; KIAA0070 antibody; Lysine--tRNA ligase antibody; EC 2.7.7.- antibody; EC 6.1.1.6 antibody; Lysyl-tRNA synthetase antibody; LysRS antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human KARS1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.; (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
  • 基因功能參考文獻(xiàn)：
    1. The studies showed that mutations in KARS lead to a newly defined subtype of leukoencephalopathy associated with sensorineural hearing impairment. The combined effect of reduced aminoacylation and release of LysRS from the multiple-synthetase complex (MSC) likely underlies the pathogenesis of the KARS mutations identified in this study. PMID: 28887846
    2. Using the TruSight One sequencing panel we identified two novel mutations in KARS. Both mutations, never reported previously, occur in a highly conserved region of the catalytic domain and displayed a dramatic effect on KARS stability PMID: 27891585
    3. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from colorectal cancer cells. PMID: 28611052
    4. Results indicate that KRS can promote cell-cell and cellextracellular matrix adhesion for migration. PMID: 26891990
    5. finding show that enzymatically active Shiga toxins trigger the dissociation of lysyl-tRNA synthetase (KRS) from the multi-aminoacyl-tRNA synthetase complex in human macrophage-like differentiated THP-1 cells and its subsequent secretion. PMID: 26643967
    6. KRS at the plasma membrane plays new roles in metastatic migration as a signaling inducer, and causes intracellular signaling for cancer dissemination PMID: 26091349
    7. tRK1 forms a complex with human enolases and interacts with tRK1 and human pre-lysyl-tRNA synthetase (preKARS2) PMID: 25918939
    8. structural characteristics of the KRS-LR interaction on the cell surface PMID: 24983501
    9. Lysyl-tRNA synthetase plays essential role in HIV replication, transcriptional regulation, cytokine-like signaling. [review] PMID: 23972532
    10. The role of preKARS2 in the tRNA mitochondrial import. PMID: 23799079
    11. The KARS variant is identified in two families affected by DFNB89-associated autosomal-recessive nonsyndromic hearing impairment. PMID: 23768514
    12. C-terminal domain of HIV-1 capsid protein as surrogate for human lysyl tRNA synthetase PMID: 23208549
    13. A single conformational change triggered by phosphorylation leads to multiple effects driving an exclusive switch of LysRS function from translation to transcription. PMID: 23159739
    14. Dual role for motif 1 residues of human lysyl-tRNA synthetase in dimerization and packaging into HIV-1. PMID: 23095741
    15. The work thus unveiled a unique function of KRS in the control of cell migration and its pathological implication in metastasis. PMID: 22751010
    16. Data are consistent with hypothesis that maturation of cytoplasmic KARS precursor is needed to reveal the potent tRNA binding properties of mitochondrial KARS. PMID: 22235746
    17. LysRS associates with the Pol domain of GagPol. PMID: 21763493
    18. The results suggest that this unique geometry, which reconfigures the LysRS tetramer from alpha(2):alpha(2) to alpha(2)beta(1):beta(1)alpha(2), is designed to control both retention and mobilization of LysRS from the multi-tRNA synthetase complex PMID: 21536907
    19. The interaction between helix 7 of LysRS and helix 4 of the capsid C-terminal domain of HIV-1 Gag (HIV-CA-CTD) was studied using circular dichromism spectroscopy and molecular dynamics simulation. PMID: 21093454
    20. These results underscore the contribution of KARS to the emission of (one of) the principal signal(s) of immunogenic cell death, CRT exposure. PMID: 20699648
    21. Loss-of-function lysyl-tRNA synthetase mutations associated with peripheral neuropathy and Charcot-Marie-Tooth disease. PMID: 20920668
    22. HIV-1 Gag interacts with human lysyl-tRNA synthetase during viral assembly PMID: 12756246
    23. packaged into human immunodeficiency virus type 1 (HIV-1) via its interaction with Gag; this enzyme facilitates the selective packaging of tRNA(3)(Lys), the primer for initiating reverse transcription, into HIV-1 PMID: 15220430
    24. analysis of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase PMID: 16702215
    25. HIV-1 Vpr fulfills an essential role in the process of packaging of mitochondrial Lysyl-tRNA synthase. PMID: 17560997
    26. This work reports further characterization of the interaction between HIV-1 capsid domain of Gag and human LysRS using truncation constructs and point mutations in the putative interaction helices. PMID: 17724017
    27. present a 2.3-A crystal structure of a tetrameric form of human LysRS PMID: 18272479
    28. mitoKARS is the first described member of a group of mitochondrial proteins whose interaction with mutant SOD1 contributes to mitochondrial dysfunction in ALS PMID: 18715867

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  • 相關(guān)疾?。?/div>
    Charcot-Marie-Tooth disease, recessive, intermediate type, B (CMTRIB); Deafness, autosomal recessive, 89 (DFNB89)
  • 亞細(xì)胞定位：
    [Isoform Cytoplasmic]: Cytoplasm, cytosol. Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted.; [Isoform Mitochondrial]: Mitochondrion.
  • 蛋白家族：
    Class-II aminoacyl-tRNA synthetase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6215

    OMIM: 601421

    KEGG: hsa:3735

    STRING: 9606.ENSP00000325448

    UniGene: Hs.3100



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