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  4. IL1RAP (Nadunolimab Biosimilar) Recombinant Monoclonal Antibody

IL1RAP (Nadunolimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA878844MB5HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL1RAP (Nadunolimab Biosimilar Antibody)重組單克隆抗體是一種針對白細(xì)胞介素1受體輔助蛋白（IL1RAP）的生物制劑，主要用于科研領(lǐng)域的基礎(chǔ)研究與藥物靶點(diǎn)驗(yàn)證。該抗體通過基因工程技術(shù)重組表達(dá)，具有高特異性和親和力，能夠精準(zhǔn)識別并結(jié)合IL1RAP，從而為研究IL1RAP在炎癥反應(yīng)、免疫調(diào)節(jié)及相關(guān)疾病發(fā)生發(fā)展中的作用機(jī)制提供重要工具。 IL1RAP作為IL-1受體家族的關(guān)鍵組成部分，在IL-1信號通路中扮演重要角色，參與調(diào)控多種生理和病理過程，如類風(fēng)濕關(guān)節(jié)炎、腫瘤微環(huán)境調(diào)節(jié)等。通過使用IL1RAP重組單克隆抗體，研究人員可深入探究IL1RAP的分子功能、信號轉(zhuǎn)導(dǎo)途徑以及與疾病的關(guān)聯(lián)，為開發(fā)新型治療策略提供理論依據(jù)。 該抗體適用于多種實(shí)驗(yàn)技術(shù)，可用于檢測細(xì)胞或組織中IL1RAP的表達(dá)水平、亞細(xì)胞定位及相互作用蛋白。其高度純化的特性確保了實(shí)驗(yàn)結(jié)果的可靠性和可重復(fù)性，為科研人員提供穩(wěn)定的研究材料。 在科研應(yīng)用中，IL1RAP重組單克隆抗體有助于揭示IL1RAP相關(guān)信號通路的調(diào)控網(wǎng)絡(luò)，推動炎癥性疾病、自身免疫性疾病及腫瘤等領(lǐng)域的機(jī)制研究，為潛在治療靶點(diǎn)的發(fā)現(xiàn)和驗(yàn)證奠定基礎(chǔ)。目前，該產(chǎn)品僅作為科研工具使用，尚未進(jìn)入臨床應(yīng)用階段，其研發(fā)與應(yīng)用旨在支持生命科學(xué)領(lǐng)域的基礎(chǔ)研究和藥物研發(fā)進(jìn)程。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CAN04 research-grade biosimilar; CAN-04 research-grade biosimilar; Nidanilimab research-grade biosimilar ;IL1RAP antibody; C3orf13 antibody; IL1R3 antibody; Interleukin-1 receptor accessory protein antibody; IL-1 receptor accessory protein antibody; IL-1RAcP antibody; EC 3.2.2.6 antibody; Interleukin-1 receptor 3 antibody; IL-1R-3 antibody; IL-1R3 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL1RAP protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).; Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.; Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
  • 基因功能參考文獻(xiàn)：
    1. Expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas PMID: 29238884
    2. These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. PMID: 27621309
    3. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    4. The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework. PMID: 26268530
    5. The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk. PMID: 25517029
    6. Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis. PMID: 24935223
    7. Plasma sIL1RAP levels are reduced in obesity and can potentially act as biomarkers of obesity. PMID: 24915116
    8. Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution. PMID: 23980170
    9. Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells. PMID: 22723552
    10. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. PMID: 22778412
    11. decreased protein levels in the peritoneal fluid of women with endometriosis PMID: 21958553
    12. Studies indicate that new targets have recently been investigated as potential modulators in myeloid leukemia pathogenesis, including miR-328, BMI1, FOXOs and IL1RAP. PMID: 21373837
    13. This study showed a significant downregulation of soluble interleukin-1 receptor accessory protein expression in the endometrium of women with endometriosis. PMID: 21272866
    14. identifies IL1RAP as a unique cell surface biomarker distinguishing Ph(+) from Ph(-) candidate chronic myeloid leukemia (CML) stem cells and opens up a previously unexplored avenue for therapy of CML PMID: 20805474
    15. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling PMID: 11880380
    16. soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor PMID: 12530978
    17. The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation. PMID: 12781872
    18. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP in Jurkat cells PMID: 14734551
    19. Specific destabilization of membrane-bound IL-1 receptor accessory protein mRNA in HepG2 hepatoma cells is mediated by its 2.8-kilobase 3'-untranslated region. PMID: 15528363
    20. Analysis of a three-dimensional docking model of the TIR-TIR interaction between MyD88 and IL1RAcP PMID: 15849357
    21. IL-1ra is associated with preserved beta-cell capacity in type 1 diabetes. PMID: 18299313
    22. an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS. PMID: 19481478

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5995

    OMIM: 602626

    KEGG: hsa:3556

    UniGene: Hs.478673



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