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  4. CLEC6A (BDC-3042 Biosimilar) Recombinant Monoclonal Antibody

CLEC6A (BDC-3042 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA738603MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC6A(BDC-3042 Biosimilar Antibody)重組單克隆抗體是一種專為科研實(shí)驗(yàn)設(shè)計(jì)的高性能生物試劑，旨在助力免疫學(xué)、細(xì)胞生物學(xué)及相關(guān)領(lǐng)域的研究工作。該抗體針對(duì)C型凝集素 domain family 6 member A（CLEC6A）靶點(diǎn)設(shè)計(jì)，具有高度的特異性和親和力，能夠精準(zhǔn)識(shí)別并結(jié)合CLEC6A蛋白，為研究其在天然免疫調(diào)節(jié)、病原體識(shí)別及炎癥反應(yīng)中的分子機(jī)制提供可靠工具。 CLEC6A作為模式識(shí)別受體家族成員，在巨噬細(xì)胞、樹(shù)突狀細(xì)胞等免疫細(xì)胞表面表達(dá)，參與真菌及細(xì)菌感染的識(shí)別與信號(hào)傳導(dǎo)過(guò)程。通過(guò)使用本抗體，研究人員可開(kāi)展等多種實(shí)驗(yàn)，深入探究CLEC6A在免疫激活、細(xì)胞通訊及疾病發(fā)生發(fā)展中的作用。 該抗體采用重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞中表達(dá)，經(jīng)過(guò)嚴(yán)格的純化和質(zhì)量控制流程，確保產(chǎn)品具有低內(nèi)毒素水平、高批次一致性和良好的穩(wěn)定性。其優(yōu)化的緩沖液體系適合長(zhǎng)期保存，且在多種實(shí)驗(yàn)條件下均能保持優(yōu)異的結(jié)合活性，為科研人員提供穩(wěn)定可靠的實(shí)驗(yàn)結(jié)果。 CLEC6A重組單克隆抗體的應(yīng)用將推動(dòng)對(duì)天然免疫信號(hào)通路、 infectious disease pathogenesis以及免疫相關(guān)疾病機(jī)制的研究，為開(kāi)發(fā)新型診斷標(biāo)志物和治療靶點(diǎn)提供重要的實(shí)驗(yàn)基礎(chǔ)。本產(chǎn)品僅用于科研用途，不用于臨床診斷或治療。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BDC3042 research-grade biosimilar; BDC 3042 research-grade biosimilar ;CLEC6A antibody; CLECSF10 antibody; DECTIN2 antibody; C-type lectin domain family 6 member A antibody; C-type lectin superfamily member 10 antibody; Dendritic cell-associated C-type lectin 2 antibody; DC-associated C-type lectin 2 antibody; Dectin-2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC6A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
  • 基因功能參考文獻(xiàn)：
    1. functions in Kupffer cells to mediate the uptake and clearance of cancer cells PMID: 27872290
    2. Data suggest that the specificity and geometry of dectin-2/CLEC6A carbohydrate-binding site provide molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain mannose-alpha-1--2-mannose disaccharide unit. (CLEC6A = C-type lectin domain containing 6A) PMID: 28652405
    3. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. PMID: 27358401
    4. This study showed a genetic association between Dectin-2 and pulmonary cryptococcosis. PMID: 26129889
    5. human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-2 PMID: 25659141
    6. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation. PMID: 24129160
    7. The Dectin-2 possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. PMID: 23606632
    8. human DECTIN-2 has a role in innate immunity PMID: 15810886

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14556

    OMIM: 613579

    KEGG: hsa:93978

    STRING: 9606.ENSP00000371505

    UniGene: Hs.591147



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