日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級(jí)生物類似抗體
  4. CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody

CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA2267MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLC (ARGX-118 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開(kāi)發(fā)的生物試劑。該產(chǎn)品基于重組DNA技術(shù)制備，通過(guò)將特定的抗體基因片段導(dǎo)入宿主細(xì)胞，經(jīng)培養(yǎng)、純化等工藝獲得高純度的單克隆抗體。其核心成分是具有明確靶向性的免疫球蛋白分子，能夠特異性識(shí)別并結(jié)合靶抗原，為生命科學(xué)研究提供可靠的分子工具。 在科研應(yīng)用中，該抗體可廣泛用于細(xì)胞生物學(xué)、分子免疫學(xué)、蛋白質(zhì)組學(xué)等領(lǐng)域的實(shí)驗(yàn)研究。例如，在細(xì)胞水平的檢測(cè)中，可通過(guò)等技術(shù)分析靶蛋白的表達(dá)定位；在蛋白質(zhì)相互作用研究中，可用于某些實(shí)驗(yàn)，助力揭示生物分子間的調(diào)控機(jī)制。此外，該重組單克隆抗體還可作為陽(yáng)性對(duì)照或標(biāo)準(zhǔn)品，用于實(shí)驗(yàn)體系的優(yōu)化與驗(yàn)證，確保研究結(jié)果的準(zhǔn)確性和可重復(fù)性。 產(chǎn)品在生產(chǎn)過(guò)程中嚴(yán)格遵循質(zhì)量控制標(biāo)準(zhǔn)，通過(guò)多種檢測(cè)手段保證抗體的純度、活性及批次間一致性。其穩(wěn)定的理化性質(zhì)使其適合長(zhǎng)期儲(chǔ)存和多次凍融，為科研人員提供便捷的實(shí)驗(yàn)條件。作為科研用試劑，該產(chǎn)品為探索生命現(xiàn)象、解析疾病機(jī)制等基礎(chǔ)研究及藥物研發(fā)早期階段的靶點(diǎn)驗(yàn)證提供了有力支持，有助于推動(dòng)生物醫(yī)學(xué)領(lǐng)域的科學(xué)發(fā)現(xiàn)與技術(shù)創(chuàng)新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CLC antibody; LGALS10 antibody; LGALS10A antibody; Galectin-10 antibody; Gal-10 antibody; Charcot-Leyden crystal protein antibody; CLC antibody; Eosinophil lysophospholipase antibody; Lysolecithin acylhydrolase antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLC protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
  • 基因功能參考文獻(xiàn)：
    1. findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils PMID: 28515279
    2. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation. PMID: 22880030
    3. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
    4. DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
    5. Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis PMID: 19650845
    6. downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells PMID: 12031912
    7. Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages. PMID: 12714580
    8. The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques PMID: 16015083
    9. Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
    10. expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells. PMID: 17502455
    11. Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion. PMID: 19758173

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
  • 組織特異性：
    Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2014

    OMIM: 153310

    KEGG: hsa:1178

    STRING: 9606.ENSP00000221804

    UniGene: Hs.889



×
生命科學(xué)計(jì)算平臺(tái)