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  4. CEACAM8 (Besilesomab Biosimilar) Recombinant Monoclonal Antibody

CEACAM8 (Besilesomab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA005168MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CEACAM8 (Besilesomab Biosimilar Antibody) 重組單克隆抗體是一種針對人癌胚抗原相關細胞黏附分子8（CEACAM8），其別名為癌胚抗原CGM6抗體、CD66b抗體、CD67抗體、NCA95抗體等，對應靶標包括CEACAM8、CD66b、CD67等多種抗原分子。該抗體以重組人CEACAM8蛋白制備，具有高度的人源種屬反應性。 Besilesomab Biosimilar Antibody作為靶向CEACAM8抗體，Besilesomab的類似物，基于CEACAM8在中性粒細胞等免疫細胞表面的高表達特性，其臨床潛力聚焦于通過調節(jié)中性粒細胞功能，為炎癥反應相關疾?。ㄈ缂毙匝装Y或慢性炎癥性疾?。┨峁┲委熕悸贰Ｍ瑫r，針對CEACAM8在部分腫瘤組織中的異常表達，該抗體研發(fā)的藥物也在臨床試驗中被評估用于腫瘤顯像及免疫治療的價值，探索其作為潛在診斷標志物和治療靶點的應用前景。 該抗體可用于檢測CEACAM8的表達與定位，適用于實驗，助力研究CEACAM8在免疫細胞分化、炎癥信號通路及腫瘤發(fā)生發(fā)展中的分子機制。其高特異性和種屬反應性確保了實驗結果的可靠性，為深入解析CEACAM8的生物學功能及相關疾病的病理機制提供了重要工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Carcinoembryonic antigen CGM6 antibody; Carcinoembryonic antigen gene family member 6 antibody; Carcinoembryonic antigen related cell adhesion molecule 8 antibody; Carcinoembryonic antigen-related cell adhesion molecule 8 antibody; CD 66b antibody; CD 67 antibody; CD66b antibody; CD66b antigen antibody; CD67 antibody; CD67 antigen antibody; CEACAM 8 antibody; CEACAM8 antibody; CEAM8_HUMAN antibody; CGM 6 antibody; CGM6 antibody; NCA 95 antibody; NCA95 antibody; Non-specific cross-reacting antigen NCA-95 antibody; Nonspecific cross reacting antigen NCA 95 antibody; Nonspecific cross reacting antigen NCA95 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CEACAM8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能參考文獻：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 組織特異性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 數據庫鏈接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41



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