日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. CEACAM8 Recombinant Monoclonal Antibody

CEACAM8 Recombinant Monoclonal Antibody

  • 中文名稱(chēng)：
    CEACAM8重組抗體
  • 貨號(hào)：
    CSB-RA937940A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate(30μg), BxPC-3 whole cell lysate(30μg), JK whole cell lysate(30μg), HepG2 whole cell lysate(30μg), HT29 whole cell lysate(30μg),THP-1 whole cell lysate(30μg),Raji whole cell lysate(30μg),A549 whole cell lysate(30μg),Mouse Spleen tissue lysate(20μg)
      All lanes: CEACAM8 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 39, 70-100 kDa
      Observed band size: 39,100 kDa
      Exposure time: 120s
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CEACAM8重組單克隆抗體（CUSABIO貨號(hào)：CSB-RA937940A0HU）是針對(duì)粒細(xì)胞特異性標(biāo)志物CEACAM8開(kāi)發(fā)的高特異性檢測(cè)工具。CEACAM8作為癌胚抗原相關(guān)細(xì)胞黏附分子家族成員，在中性粒細(xì)胞活化、炎癥反應(yīng)及病原體防御中發(fā)揮重要作用。本產(chǎn)品經(jīng)過(guò)嚴(yán)格的ELISA和流式細(xì)胞術(shù)（FC）驗(yàn)證，能特異性識(shí)別天然構(gòu)象的CEACAM8蛋白，F(xiàn)C推薦使用稀釋比為1:50-1:200，適用于體外檢測(cè)人源樣本中CEACAM8的表達(dá)水平。在科研領(lǐng)域，該抗體可應(yīng)用于粒細(xì)胞亞群分型、炎癥相關(guān)免疫細(xì)胞功能研究，以及感染性疾病或自身免疫性疾病模型中粒細(xì)胞活化機(jī)制的探索。其重組單克隆特性保障了批次間的高度一致性，為細(xì)胞表面標(biāo)記分析、免疫應(yīng)答機(jī)制研究提供可靠工具，助力研究者深入解析CEACAM8在先天免疫調(diào)控中的生物學(xué)功能。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b), CEACAM8, CGM6
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from Human CEACAM8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    24H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.
  • 基因功能參考文獻(xiàn)：
    1. Increased CD66b positive tumor-infiltrating neutrophils (CD66b + TINs) was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. PMID: 27863478
    2. Data suggest ways in which carcinoembryonic antigen-related cell adhesion molecules CEACAM6 and CEACAM8 regulate the biological functions of one another. PMID: 26483485
    3. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls. PMID: 23686079
    4. The highly elevated gene expression of CEACAM6 and CEACAM8 in primary myelofibrosis can serve as molecular markers of myelofibrotic transformation. PMID: 21470677
    5. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes. PMID: 17909799
    6. CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. PMID: 18056392

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell surface.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 組織特異性：
    Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1820

    OMIM: 615747

    KEGG: hsa:1088

    STRING: 9606.ENSP00000244336

    UniGene: Hs.41



×
生命科學(xué)計(jì)算平臺(tái)