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  4. CD3D (nebratamig2 Biosimilar) Recombinant Monoclonal Antibody

CD3D (nebratamig2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004930MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD3D (nebratamig2 Biosimilar Antibody) 重組單克隆抗體，其是重組人CD3D蛋白，主要針對人CD3D分子，種屬反應(yīng)性為人類。該產(chǎn)品擁有眾多別名，如CD3 delta antibody、CD3d antigen、delta polypeptide、T cell surface glycoprotein CD3 delta chain antibody等，反映了其與CD3分子家族各亞基及相關(guān)復(fù)合物的密切關(guān)聯(lián)，包括T細(xì)胞受體T3 delta鏈、T - cell antigen receptor complex等，也被稱為OKT3、Leu - 4等。 CD3靶向藥物展現(xiàn)出重要潛力。鑒于CD3分子在T細(xì)胞活化中不可或缺的作用，其靶向藥物可能成為免疫相關(guān)疾病治療的關(guān)鍵選擇。目前相關(guān)藥物研究可能聚焦于器官移植后的免疫排斥反應(yīng)防治，通過特異性結(jié)合T細(xì)胞表面CD3分子，調(diào)節(jié)T細(xì)胞功能，抑制過度免疫應(yīng)答。此外，在自身免疫性疾病如類風(fēng)濕關(guān)節(jié)炎、多發(fā)性硬化癥等領(lǐng)域，CD3靶向藥物或許能通過調(diào)控免疫系統(tǒng)失衡，為疾病治療提供新策略，相關(guān)臨床試驗(yàn)可能正在評估其療效與安全性。 CD3D Biosimilar Antibody應(yīng)用廣泛。作為特異性抗體工具，可用于識別和檢測T細(xì)胞表面CD3D分子的表達(dá)，助力研究T細(xì)胞的發(fā)育、活化機(jī)制及信號轉(zhuǎn)導(dǎo)通路。在細(xì)胞生物學(xué)實(shí)驗(yàn)里，能通過技術(shù)，分析CD3D在不同組織、細(xì)胞系中的分布與表達(dá)水平變化，為探究T細(xì)胞相關(guān)疾病的發(fā)病機(jī)制提供關(guān)鍵實(shí)驗(yàn)數(shù)據(jù)，也可用于構(gòu)建細(xì)胞模型或動物模型，深入研究免疫調(diào)節(jié)相關(guān)過程。
  • Uniprot No.：
  • 基因名：
  • 別名：
    4930549J05Rik antibody; A430104F18Rik antibody; AW552088 antibody; Cd247 antibody; CD247 antigen antibody; CD247 antigen; zeta subunit antibody; CD247 molecule antibody; CD3 antibody; CD3 antigen; delta subunit antibody; CD3 delta antibody; CD3 epsilon antibody; CD3 eta antibody; CD3 gamma antibody; CD3 molecule delta polypeptide antibody; CD3 molecule; epsilon polypeptide antibody; CD3 molecule; gamma polypeptide antibody; CD3 zeta antibody; CD3-DELTA antibody; CD3d antibody; CD3D antigen delta polypeptide antibody; CD3d antigen; delta polypeptide；TiT3 complex antibody; CD3d molecule delta antibody; CD3d molecule delta CD3 TCR complex antibody; CD3d molecule; delta；CD3-TCR complex antibody; CD3D_HUMAN antibody; CD3E antibody; CD3e antigen antibody; CD3E antigen epsilon polypeptide antibody; CD3e antigen; epsilon polypeptide；TiT3 complex antibody; CD3e molecule epsilon antibody; CD3e molecule epsilon CD3 TCR complex antibody; CD3e molecule; epsilon；CD3-TCR complex antibody; CD3epsilon antibody; CD3G antibody; CD3g antigen antibody; CD3G antigen gamma polypeptide antibody; CD3g antigen; gamma polypeptide；TiT3 complex antibody; CD3g molecule gamma antibody; CD3g molecule gamma CD3 TCR complex antibody; CD3g molecule; gamma；CD3-TCR complex antibody; CD3H antibody; CD3Q antibody; CD3Z antibody; CD3zeta antibody; Ctg3 antibody; FLJ17620 antibody; FLJ17664 antibody; FLJ18683 antibody; FLJ79544 antibody; FLJ94613 antibody; IMD19 antibody; Leu-4 antibody; MGC138597 antibody; OKT3; delta chain antibody; OTTHUMP00000032544 antibody; T cell receptor antibody; T cell receptor T3 delta chain antibody; T cell receptor T3 gamma chain antibody; T cell receptor T3 zeta chain antibody; T cell receptor zeta chain antibody; T cell surface antigen T3/Leu 4 epsilon chain antibody; T cell surface glycoprotein CD3 antibody; T cell surface glycoprotein CD3 delta chain antibody; T cell surface glycoprotein CD3 epsilon chain antibody; T cell surface glycoprotein CD3 gamma chain antibody; T cell surface glycoprotein CD3 zeta chain antibody; T-cell antigen receptor complex; delta subunit of T3 antibody; T-cell antigen receptor complex; epsilon subunit of T3 antibody; T-cell antigen receptor complex; gamma subunit of T3 antibody; T-cell antigen receptor complex; zeta subunit of CD3 antibody; T-cell receptor T3 delta chain antibody; T-cell receptor T3 gamma chain antibody; T-cell surface antigen T3/Leu-4 epsilon chain antibody; T-cell surface glycoprotein CD3 delta chain antibody; T-cell surface glycoprotein CD3 epsilon chain antibody; T-cell surface glycoprotein CD3 gamma chain antibody; T3 antibody; T3d antibody; T3e antibody; T3g antibody; T3z antibody; TCRE antibody; TCRk antibody; Tcrz antibody; TCRzeta antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD3D protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
  • 基因功能參考文獻(xiàn)：
    1. PCR and transcriptome analysis suggest that the genes CD3D and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia. PMID: 27494091
    2. we demonstrate that the incorporation of a 2A self-processing peptide derived from foot-and-mouth disease virus conveying co-translational cleavage into a two-chain anti-CD3 x anti-CEA diabody gene enables near-equimolar expression of diabody chains 1 and 2, and thus increases the final amount of assembled diabody. PMID: 28075428
    3. A FOXP3(+)CD3(+)CD56(+)-expressed T-cell population with immunosuppressive function and reduced patient survival has been identified in cancer tissues of human hepatocellular carcinoma. PMID: 26437631
    4. The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR. PMID: 26109064
    5. analysis of the molecular organization of the TCR-CD3 complex PMID: 25422432
    6. Two cases of SCID with CD3delta gene mutation in Mexican Mennonite infants are described. PMID: 24288697
    7. The surface TCR expression of primary alphabeta and gammadelta T cells from healthy donors carrying a single null or leaky mutation in CD3G (gamma+/-) or CD3D (delta+/-, delta+/leaky) with that of normal controls, were compared. PMID: 23336327
    8. Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia. PMID: 22401598
    9. A transgenic T cell receptor gammadelta-low expressing subset of T cells accumulates in mouse ear keratinocytes after IL-23 injections. PMID: 21984702
    10. report 2 unrelated cases of SCID with a selective block in alphabeta but not in gammadelta T cell development, associated with a new splicing mutation in the CD3D gene PMID: 21926461
    11. Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls. PMID: 21669053
    12. Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta. PMID: 21669059
    13. A combination of trastuzumab antibody and phosphoantigen-stimulated gammadelta T-lymphocytes increases the efficacy of trastuzumab alone against HER-2-positive breast carcinoma cell lines in vivo and mammary carcinoma xenografts in mice. PMID: 21670311
    14. Protein sequence comparison indicates that the CD3elta and CD3gamma subunits evolved with highly homologous heterodimeric interfaces and membrane proximal segments for efficient and specific signaling transfer when paired with CD3epsilon. PMID: 20660709
    15. When compared with other human T cell subsets, T cell receptor/CD3-activated Vgamma9Vdelta2-expressing T cells display an unusually delayed and sustained intracellular calcium mobilization, dramatically quickened and shortened on costimulation by NKG2D. PMID: 20511557
    16. CD3 epsilon undergoes a conformational change after dimerization with CD3 gamma or CD3 delta PMID: 12410792
    17. defect in CD3delta gene in severe combined immunodeficiency is characterized by the absence of T cells but normal B cells PMID: 14602880
    18. crystal structure at 1.9-A resolution of a complex between a CD3-epsilon/delta ectodomain heterodimer and a single-chain fragment of the UCHT1 antibody PMID: 15534202
    19. SCID is caused by a CD3D deficiency. PMID: 15546002
    20. a single, membrane-distal YxxO motif in CD3delta could mediate approximately 75% of receptor internalization, whereas its removal only reduced internalization by approximately 20% PMID: 15778375
    21. A human CD3 transgene that encodes full length CD3delta and a truncated but functional form of CD3epsilon restored the defective preTCR function in not only CD3epsilon- but CD3gamma- and CD3gammadelta-deficient mice as well. PMID: 16412509
    22. CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development PMID: 16888097
    23. analysis of TCRalpha-CD3deltaepsilon and TCRbeta-CD3gammaepsilon dimers and the role of the membrane-proximal tetracysteine motif PMID: 17023417
    24. The CD3 delta immune recognition receptor cytoplasmic domain binds to acidic and mixed phospholipid vesicles with a binding strength that correlates with the protein net charge and the presence of clustered basic amino acid residues. PMID: 17176095
    25. In CD3gamma-deficient patients there can be substitution of CD3gamma by the CD3delta chain and which can then support gammadelta T cell development. PMID: 17923503
    26. Enumeration of NK cells and of T lymphocytes expressing TCR alpha/beta in human body effusions is not helpful in attempting to distinguish between benign and malignant effusions. PMID: 18803280
    27. Stage-dependent molecular changes in Notch signaling that are critical for normal human T-cell development. PMID: 19056690
    28. Data show CD3 epsilon pairs with CD3 gamma or with CD3 delta, forming CD3 epsilon gamma and CD3 epsilon delta heterodimers, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex. PMID: 19724882

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  • 相關(guān)疾?。?/div>
    Immunodeficiency 19 (IMD19)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1673

    OMIM: 186790

    KEGG: hsa:915

    STRING: 9606.ENSP00000300692

    UniGene: Hs.504048



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