CNTN6 Antibody

產(chǎn)品詳情

Uniprot No.：

Q9UQ52
基因名：

CNTN6
別名：

CNTN 6 antibody; CNTN6 antibody; CNTN6_HUMAN antibody; Contactin 6 precursor antibody; Contactin-6 antibody; Contactin6 antibody; hNB 3 antibody; hNB-3 antibody; hNB3 antibody; MGC133256 antibody; NB 3 antibody; NB3 antibody; Neural adhesion molecule antibody; Neural recognition molecule NB 3 antibody; Neural recognition molecule NB-3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human Contactin 6.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
基因功能參考文獻(xiàn)：
1. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway. PMID: 27166760
2. CNTN6 copy number variants (duplications) were associated with increased risk of Tourette syndrome. PMID: 28641109
亞細(xì)胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Immunoglobulin superfamily, Contactin family
組織特異性：

Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
數(shù)據(jù)庫鏈接：

HGNC: 2176

OMIM: 607220

KEGG: hsa:27255

STRING: 9606.ENSP00000341882

UniGene: Hs.387300