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ZPR1

ZPR1,全稱為鋅指蛋白ZPR1,也常被稱為ZNF259。它是細(xì)胞內(nèi)一種重要的調(diào)節(jié)蛋白,在維持細(xì)胞正常生長(zhǎng)和分裂中發(fā)揮關(guān)鍵作用:參與核糖體的組裝過(guò)程,助力細(xì)胞合成所需的蛋白質(zhì);同時(shí)能在細(xì)胞面臨營(yíng)養(yǎng)不足、DNA損傷等外界壓力時(shí),調(diào)控細(xì)胞的應(yīng)對(duì)方式,避免細(xì)胞異常增殖或死亡。
ZPR1功能異常與多種疾病相關(guān):在肺癌、乳腺癌等癌癥中,其表達(dá)水平常發(fā)生改變,影響腫瘤細(xì)胞的生長(zhǎng)與侵襲能力;此外,它參與的蛋白質(zhì)合成過(guò)程對(duì)神經(jīng)細(xì)胞存活至關(guān)重要,因此也可能與某些神經(jīng)退行性疾病的發(fā)生有關(guān)。目前針對(duì)ZPR1的藥物研發(fā)仍處于早期階段,研究人員主要探索其作為潛在治療靶點(diǎn)的價(jià)值,嘗試開發(fā)調(diào)節(jié)其活性的小分子化合物,為相關(guān)疾病治療提供新方向。

熱銷產(chǎn)品

Recombinant Human Zinc finger protein ZPR1 (ZPR1) (CSB-EP026617HU)

驗(yàn)證數(shù)據(jù)

CSB-EP026617HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ZPR1 Recombinant Monoclonal Antibody (CSB-RA597488A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA597488A0HU

Flow cytometric analysis of ZPR1 zinc finger expression in HepG2 cells using ZPR1 zinc finger antibody. Green, isotype control; red, ZPR1 zinc finger.

CSB-RA597488A0HU

Immunocytochemical staining of HepG2 cells with ZPR1 zinc finger antibody. Nuclei were stained blue with DAPI; ZPR1 zinc finger was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA597488A0HU

Western blotting analysis using ZPR1 zinc finger antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ZPR1 zinc finger antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

ZPR1 Antibody (CSB-PA890972)

驗(yàn)證數(shù)據(jù)

CSB-PA890972

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA890972(ZPR1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA890972

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA890972(ZPR1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA890972

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA890972(ZPR1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds

ZPR1 Antibodies

ZPR1 for Homo sapiens (Human)

ZPR1 Proteins

ZPR1 Proteins for Homo sapiens (Human)



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