ZNRF3（Zinc and Ring Finger 3）屬于RING（Really Interesting New Gene）指環(huán)蛋白家族，它包含一個(gè)RING結(jié)構(gòu)域，這是一個(gè)特定類型的結(jié)構(gòu)域，具有E3泛素連接酶活性。ZNRF3的主要功能之一是調(diào)節(jié)細(xì)胞膜上受體和蛋白質(zhì)的穩(wěn)定性。它通過(guò)將泛素分子附加到目標(biāo)蛋白質(zhì)上，標(biāo)記它們以進(jìn)行降解。這個(gè)過(guò)程被稱為泛素化，是細(xì)胞對(duì)于調(diào)控蛋白質(zhì)水平和信號(hào)通路的重要機(jī)制之一。在癌癥研究領(lǐng)域，ZNRF3與Wnt信號(hào)通路的調(diào)控有關(guān)，該信號(hào)通路在多種癌癥中起關(guān)鍵作用。

熱銷產(chǎn)品

Recombinant Human E3 ubiquitin-protein ligase ZNRF3(ZNRF3),partial (Active) CSB-MP890933HU

驗(yàn)證數(shù)據(jù)

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZNRF3 at 5 μg/ml can bind Human RSPO2 (CSB-MP751021HU1(M)), the EC₅₀ is 5.091-6.991 ng/mL.