Wnt3a
Wnt3a即Wnt家族成員3A，是一類分泌型糖蛋白，在機(jī)體發(fā)育和細(xì)胞生理過(guò)程中發(fā)揮關(guān)鍵作用。它通過(guò)與細(xì)胞膜上的卷曲蛋白受體及低密度脂蛋白受體相關(guān)蛋白5/6結(jié)合，穩(wěn)定細(xì)胞質(zhì)中的β-連環(huán)蛋白，使其進(jìn)入細(xì)胞核調(diào)控靶基因表達(dá)，同時(shí)也能參與調(diào)控非經(jīng)典相關(guān)通路，對(duì)細(xì)胞增殖、分化及胚胎正常發(fā)育起到重要調(diào)控作用。該蛋白異常會(huì)引發(fā)多種疾病，過(guò)度表達(dá)時(shí)會(huì)促進(jìn)結(jié)直腸癌、乳腺癌、胰腺癌等腫瘤的發(fā)生發(fā)展，而表達(dá)不足則可能導(dǎo)致胚胎發(fā)育畸形。目前相關(guān)治療研發(fā)圍繞其展開(kāi)，IWP-2等小分子物質(zhì)可抑制其分泌，處于前期研究階段；抗Wnt3a中和抗體、低密度脂蛋白受體相關(guān)蛋白6拮抗劑在動(dòng)物實(shí)驗(yàn)中展現(xiàn)出抗腫瘤效果，多款靶向Wnt3a的治療方案正針對(duì)實(shí)體腫瘤進(jìn)行臨床評(píng)估，有望為相關(guān)疾病治療提供新方向。
熱銷產(chǎn)品
Recombinant Human Protein Wnt-3a (WNT3A) (Active) (CSB-MP026136HU-WD)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Recombinant Human Protein Wnt-3a (WNT3A) (CSB-EP026136HUc7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
WNT3A Antibody (CSB-PA15549A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA15549A0Rb at dilution of 1:50
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA15549A0Rb at dilution of 1:50
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: WNT3A antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 43 kDa
Observed band size: 40 kDa
IHC image of CSB-PA15549A0Rb diluted at 1:260 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Protein Wnt-3a(WNT3A) ELISA kit (CSB-EL026136HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL026136HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測(cè)范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Wnt3a Antibodies
Wnt3a for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA15549A0Rb | WNT3A Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA026136KA01HU | WNT3A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA15549D0Rb | WNT3A Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA560286 | WNT3A Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA796998 | WNT3A Antibody | Human,Mouse | ELISA,WB,IHC |
Wnt3a Proteins
Wnt3a Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP026136MO CSB-BP026136MO CSB-MP026136MO CSB-EP026136MO-B |
Recombinant Mouse Protein Wnt-3a (Wnt3a) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP026136MO | Recombinant Mouse Protein Wnt-3a (Wnt3a) | E.coli |
Wnt3a Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP026136HU CSB-BP026136HU CSB-MP026136HU CSB-EP026136HU-B |
Recombinant Human Protein Wnt-3a (WNT3A) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP026136HU1 | Recombinant Human Protein Wnt-3a (WNT3A), partial | E.coli |
| CSB-EP026136HU | Recombinant Human Protein Wnt-3a (WNT3A) | E.coli |
| CSB-EP026136HUc7 | Recombinant Human Protein Wnt-3a (WNT3A) | E.coli |
| CSB-MP026136HU-WD | Recombinant Human Protein Wnt-3a (WNT3A) (Active) | Mammalian cell |
| CSB-EP026136HU1g5 | Recombinant Human Protein Wnt-3a (WNT3A), partial | E.coli |
| CSB-EP026136HU1c7 | Recombinant Human Protein Wnt-3a (WNT3A), partial | E.coli |
| CSB-EP026136HU1d7 | Recombinant Human Protein Wnt-3a (WNT3A), partial | E.coli |
Wnt3a Proteins for Meleagris gallopavo (Common turkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP026136MQV CSB-EP026136MQV CSB-BP026136MQV CSB-MP026136MQV CSB-EP026136MQV-B |
Recombinant Meleagris gallopavo Protein Wnt-3a (WNT3A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Wnt3a Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP026136XBE CSB-EP026136XBE CSB-BP026136XBE CSB-MP026136XBE CSB-EP026136XBE-B |
Recombinant Xenopus laevis Protein Wnt-3a (wnt3a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Wnt3a Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP641688CH CSB-EP641688CH CSB-BP641688CH CSB-MP641688CH CSB-EP641688CH-B |
Recombinant Chicken Protein Wnt-3a (WNT3A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Wnt3a ELISA Kit
Wnt3a ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL026136HU | Human Protein Wnt-3a(WNT3A) ELISA kit | serum, plasma | 0.039 ng/mL |
Wnt3a ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL026136MO | Mouse Protein Wnt-3a(WNT3A) ELISA kit | serum, plasma, tissue homogenates | 5.8 pg/mL |
