WRN
WRN，即Werner綜合征蛋白，它是一種多功能的DNA解旋酶，屬于RecQ解旋酶家族的一員。WRN在細(xì)胞核中發(fā)揮作用，具有依賴于ATP的DNA解旋酶活性和3'端到5'端的外切酶活性。它的作用機制涉及到DNA復(fù)制、重組、損傷修復(fù)以及端粒的維護。WRN通過參與細(xì)胞周期調(diào)控和DNA修復(fù)信號通路，如與p53、RAD50、RAD51等蛋白相互作用，調(diào)節(jié)細(xì)胞對DNA損傷的響應(yīng)。WRN的生物學(xué)意義在于維持基因組的完整性和穩(wěn)定性，防止早衰和某些類型的癌癥。WRN基因的突變與Werner綜合征相關(guān)，這是一種早老性疾病，患者會經(jīng)歷加速的衰老過程和較高的癌癥風(fēng)險。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
WRN Antibodies
WRN for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA060086 | Phospho-WRN (S1141) Antibody | Human | WB, ELISA |
WRN Proteins
WRN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP614518HU CSB-EP614518HU CSB-BP614518HU CSB-MP614518HU CSB-EP614518HU-B |
Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP614518HU1 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1a0 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1d8 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-BP614518HU3 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Baculovirus |
