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USP14

USP14,全稱為泛素特異性蛋白酶14,是一種去泛素化酶,在細胞內(nèi)發(fā)揮著重要的調(diào)控作用。它通過去除泛素分子,調(diào)節(jié)蛋白質(zhì)的降解和穩(wěn)定性,從而影響細胞內(nèi)的多種生理過程。USP14在多種生物過程中發(fā)揮作用,包括細胞增殖、分化和凋亡等。USP14與多種疾病密切相關(guān),如癌癥、神經(jīng)退行性疾病和代謝性疾病。在癌癥中,USP14的表達異常與腫瘤的發(fā)生發(fā)展密切相關(guān),因此成為癌癥研究的重要靶點。USP14的過表達可以促進腫瘤細胞的增殖、侵襲和轉(zhuǎn)移,而抑制USP14的表達則可以抑制腫瘤細胞的生長。USP14在非酒精性脂肪肝的發(fā)生發(fā)展中也發(fā)揮著重要作用,它通過調(diào)節(jié)脂肪酸合成酶的穩(wěn)定性,影響脂肪肝的發(fā)生發(fā)展。目前,針對USP14的藥物研發(fā)取得了一定的進展,USP14抑制劑在多種癌癥和代謝性疾病的治療中展現(xiàn)出良好的應(yīng)用前景。

熱銷產(chǎn)品

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 14 (USP14) (CSB-EP025704HU)

驗證數(shù)據(jù)

CSB-EP025704HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

USP14 Recombinant Monoclonal Antibody (CSB-RA200787A0HU)

驗證數(shù)據(jù)

CSB-RA200787A0HU

Flow cytometric analysis of Ubiquitin specific peptidase 14 expression in HepG2 cells using Ubiquitin specific peptidase 14 antibody. Green, isotype control; red, Ubiquitin specific peptidase 14.

CSB-RA200787A0HU

Immunocytochemical staining of HepG2 cells with Ubiquitin specific peptidase 14 antibody. Nuclei were stained blue with DAPI; Ubiquitin specific peptidase 14 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

CSB-RA200787A0HU

Western blotting analysis using ubiquitin specific peptidase 14 antibody. Total cell lysates (20 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ubiquitin specific peptidase 14 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

USP14 Antibody (CSB-PA025704LA01HU)

驗證數(shù)據(jù)

CSB-PA025704LA01HU

Western blot
All lanes: USP14 antibody at 2µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57, 53, 55 kDa
Observed band size: 57 kDa

CSB-PA025704LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025704LA01HU at dilution of 1:100

CSB-PA025704LA01HU

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA025704LA01HU at dilution of 1:100

CSB-PA025704LA01HU

Immunofluorescent analysis of HepG2 cells cells using CSB-PA025704LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

USP14 Antibodies

USP14 for Homo sapiens (Human)

USP14 Proteins

USP14 Proteins for Homo sapiens (Human)



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