UBR5
UBR5，即泛素蛋白連接酶E3成分n-識(shí)別蛋白5，別名DD5、EDD、HYD、EDD1。UBR5屬于HECT家族的E3泛素蛋白連接酶，具有HECT結(jié)構(gòu)域，能夠通過(guò)添加泛素來(lái)修飾蛋白質(zhì)。UBR5能識(shí)別特定蛋白質(zhì)的N端降解信號(hào)，并促進(jìn)這些蛋白質(zhì)的泛素化和隨后的降解。UBR5參與DNA損傷反應(yīng)、代謝、轉(zhuǎn)錄和凋亡的調(diào)節(jié)，是泛素-蛋白酶體系統(tǒng)（UPS）在癌癥和發(fā)育過(guò)程中的關(guān)鍵調(diào)節(jié)因子。UBR5的異常表達(dá)或突變可能導(dǎo)致細(xì)胞內(nèi)蛋白質(zhì)的異常積累或降解，影響細(xì)胞的正常功能和生理平衡，為腫瘤增殖、轉(zhuǎn)錄調(diào)控和腫瘤免疫逃逸提供有利條件，最終促進(jìn)腫瘤的發(fā)生。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EDD antibody.
Western blot analysis of extracts from A549 cells, using EDD antibody.
Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using EDD antiobdy. The lane on the left is treated with systhesized peptide.
UBR5 Antibodies
UBR5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA083120 | UBR5 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA004376 | UBR5 Antibody | Human | IHC, ELISA |
UBR5 Proteins
UBR5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP025520HU CSB-EP025520HU CSB-BP025520HU CSB-MP025520HU CSB-EP025520HU-B |
Recombinant Human E3 ubiquitin-protein ligase UBR5 (UBR5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP720310RA CSB-EP720310RA CSB-BP720310RA CSB-MP720310RA CSB-EP720310RA-B |
Recombinant Rat E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP770457MO CSB-EP770457MO CSB-BP770457MO CSB-MP770457MO CSB-EP770457MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
