TrEMBL
TrEMBL，即凝血因子X(jué)I，全稱(chēng)為血漿促凝血酶原激酶前體，常見(jiàn)簡(jiǎn)稱(chēng)FXI，也被稱(chēng)作PTA，是人體血漿中存在的絲氨酸蛋白酶原，以同源二聚體的形式存在于血液循環(huán)中，是機(jī)體凝血過(guò)程的重要組成部分，能推動(dòng)凝血相關(guān)物質(zhì)的生成，進(jìn)而助力血栓形成、維持正常的凝血平衡，其活性發(fā)揮需經(jīng)相關(guān)凝血因子激活，激活后可進(jìn)一步啟動(dòng)后續(xù)的凝血相關(guān)反應(yīng)。該蛋白異常會(huì)引發(fā)凝血因子X(jué)I缺乏癥，也叫C型血友病、羅森塔爾綜合征，患者在外傷、手術(shù)時(shí)易出現(xiàn)出血癥狀，蛋白水平異常升高則會(huì)增加靜脈血栓、缺血性腦梗塞等血栓性疾病的發(fā)病風(fēng)險(xiǎn)。目前針對(duì)該蛋白的藥物研發(fā)聚焦于抗凝與止血兩大方向，歐洲已有兩款凝血因子X(jué)I濃縮劑用于臨床有限治療，低分子抑制劑Asundexian等靶向抑制劑處于臨床研究階段，這類(lèi)藥物有望在降低出血風(fēng)險(xiǎn)的同時(shí)實(shí)現(xiàn)抗凝效果，新鮮冰凍血漿仍是目前臨床常用的應(yīng)急止血手段。
熱銷(xiāo)產(chǎn)品
Recombinant Macaca mulatta Coagulation factor XI (Active) (CSB-MP5433MOW)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta F11 at 2 μg/ml can bind Anti-F11 recombinant antibody (CSB-RA007916MA1HU). The EC50 is 0.5654-0.6444 ng/mL.
Activity
Measured by its ability to cleave the fluorogenic peptide substrate, t-butyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin (Boc-IEGR-AMC). The specific activity is >150 pmol/min/μg.
The purity of TrEMBL was greater than 95% as determined by SEC-HPLC
TrEMBL Proteins
TrEMBL Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-MP5433MOW | Recombinant Macaca mulatta Coagulation factor XI (Active) | Mammalian cell |
