TSHR
促甲狀腺激素受體（TSHR）是一種位于甲狀腺濾泡細(xì)胞膜上的糖蛋白受體，全稱為甲狀腺刺激素受體。它負(fù)責(zé)感知促甲狀腺激素（TSH）或自身抗體的結(jié)合，從而調(diào)控甲狀腺激素（T3/T4）的合成與分泌。TSHR通過復(fù)雜的信號(hào)網(wǎng)絡(luò)，在人體代謝、生長發(fā)育和能量平衡中發(fā)揮核心作用。近年來，TSHR被證實(shí)與多種自身免疫性甲狀腺疾病及甲狀腺癌密切相關(guān)，使其成為生物醫(yī)藥領(lǐng)域的研究熱點(diǎn)。
TSHR的異常激活或失調(diào)與多種疾病有關(guān)。例如，Graves病患者體內(nèi)產(chǎn)生自身抗體激活TSHR，導(dǎo)致甲狀腺激素過量分泌和甲亢，并可能發(fā)展為Graves眼病，引起眼部肌肉腫脹。與之相反，橋本甲狀腺炎患者體內(nèi)存在阻斷性抗體，抑制TSHR功能并引發(fā)甲狀腺功能減退。此外，約80%的分化型甲狀腺癌呈現(xiàn)TSHR過度表達(dá)，通過激活MAPK和PI3K/AKT通路促進(jìn)腫瘤增殖及轉(zhuǎn)移?；赥SHR的分子特性，放射性碘治療已成功應(yīng)用于甲狀腺癌靶向治療。
針對TSHR功能異常引發(fā)的疾病，已形成多維度靶向治療格局。例如，CAR-T細(xì)胞療法通過基因工程改造T細(xì)胞靶向TSHR，實(shí)現(xiàn)特異性殺傷；重組TSHR類藥物如Thyrogen可增強(qiáng)甲狀腺細(xì)胞攝碘能力，賽諾璟提升rhTSH半衰期，提高術(shù)后清甲成功率；單/雙抗藥物如GensSci098單抗降低游離T4水平并抑制眼眶成纖維細(xì)胞IL-6分泌，雙抗藥物VBS-102創(chuàng)新性構(gòu)建TSHR和IGF-1R雙靶點(diǎn)阻斷機(jī)制，抑制多條通路活性，改善眼球突出。融合蛋白與基因療法如VTC-G90降低甲狀腺激素水平，基因編輯療法縮小甲狀腺體積，為治療甲狀腺相關(guān)疾病提供了新的方向。
熱銷產(chǎn)品
Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) (CSB-MP025131HU)
驗(yàn)證數(shù)據(jù)
CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
Recombinant Human Thyrotropin receptor (TSHR), partial (CSB-BP025131HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The purity of TSHR was greater than 95% as determined by SEC-HPLC
TSHR Antibodies
TSHR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA11189D0Rb | TSHR Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11189C0Rb | TSHR Antibody, FITC conjugated | Human | |
| CSB-PA11189B0Rb | TSHR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11189A0Rb | TSHR Antibody | Human | ELISA, IF |
| CSB-PA025131GA01HU | TSHR Antibody | Human,Mouse | ELISA,WB |
| CSB-PA973863 | TSHR Antibody | Human | ELISA,IHC |
| CSB-PA820027 | TSHR Antibody | Human | ELISA,IHC |
| CSB-RA025131MA1HU | TSHR Recombinant Monoclonal Antibody | Human | ELISA |
TSHR Proteins
TSHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025131DO1 CSB-EP025131DO1 CSB-BP025131DO1 CSB-MP025131DO1 CSB-EP025131DO1-B |
Recombinant Dog Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131DO | Recombinant Dog Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025131RA1 CSB-EP025131RA1 CSB-BP025131RA1 CSB-MP025131RA1 CSB-EP025131RA1-B |
Recombinant Rat Thyrotropin receptor (Tshr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131RA | Recombinant Rat Thyrotropin receptor (Tshr) | in vitro E.coli expression system |
TSHR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025131MO CSB-EP025131MO CSB-EP025131MO-B |
Recombinant Mouse Thyrotropin receptor (Tshr), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Baculovirus |
| CSB-MP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Mammalian cell |
TSHR Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025131SH1 CSB-EP025131SH1 CSB-BP025131SH1 CSB-MP025131SH1 CSB-EP025131SH1-B |
Recombinant Sheep Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131SH | Recombinant Sheep Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP631684BO1 CSB-EP631684BO1 CSB-BP631684BO1 CSB-MP631684BO1 CSB-EP631684BO1-B |
Recombinant Bovine Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631684BO | Recombinant Bovine Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP819360PI CSB-EP819360PI CSB-BP819360PI CSB-MP819360PI CSB-EP819360PI-B |
Recombinant Pig Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858993CA1 CSB-EP858993CA1 CSB-BP858993CA1 CSB-MP858993CA1 CSB-EP858993CA1-B |
Recombinant Cat Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858993CA | Recombinant Cat Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP025131HU1 | Recombinant Human Thyrotropin receptor (TSHR), partial | Baculovirus |
| CSB-MP025131HU | Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) | Mammalian cell |
