TREX1
TREX1，全稱三素修復(fù)核酸外切酶1，是一種具有3'端核酸外切酶活性的核蛋白。它參與DNA修復(fù)過程，并作為DNA聚合酶的校對(duì)功能。TREX1的突變會(huì)導(dǎo)致多種免疫系統(tǒng)疾病，如Aicardi-Goutières綜合征、凍瘡狼瘡和Cree腦炎等。近年來，研究發(fā)現(xiàn)TREX1與自身免疫性疾病和多發(fā)性骨髓瘤的發(fā)生發(fā)展密切相關(guān)。針對(duì)TREX1的藥物研發(fā)正在興起，例如，通過CRISPR技術(shù)篩選發(fā)現(xiàn)的長非編碼RNA RP11-350G8.5可作為多發(fā)性骨髓瘤治療的新靶點(diǎn)。此外，TREX1的表達(dá)水平與腫瘤細(xì)胞的生存、增殖及對(duì)化療藥物的耐藥性密切相關(guān)，提示其可能成為治療自身免疫性疾病和腫瘤的新方向。
熱銷產(chǎn)品
Recombinant Human Three-prime repair exonuclease 1 (TREX1) (CSB-BP865133HUi2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TREX1 Antibody (CSB-PA865133ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA865133ESR1HU at dilution of 1:100
TREX1 Antibodies
TREX1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA865133ESR1HU | TREX1 Antibody | Human | ELISA, IHC |
| CSB-PA865133ESR2HU | TREX1 Antibody | Human | ELISA, IHC |
TREX1 Proteins
TREX1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP865133HU CSB-EP865133HU CSB-MP865133HU CSB-EP865133HU-B |
Recombinant Human Three-prime repair exonuclease 1 (TREX1) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP865133HU | Recombinant Human Three-prime repair exonuclease 1 (TREX1) | Baculovirus |
| CSB-EP865133HU1 | Recombinant Human Three prime repair exonuclease 1 (TREX1), partial | E.coli |
| CSB-BP865133HUi2 | Recombinant Human Three-prime repair exonuclease 1 (TREX1) | Baculovirus |
