TOMM20
TOMM20，全稱為線粒體外膜轉(zhuǎn)位酶20，是一種參與線粒體蛋白轉(zhuǎn)運(yùn)的關(guān)鍵蛋白。別名包括MAS20、MOM19和TOM20。TOMM20蛋白通過與線粒體靶向信號(hào)結(jié)合，促進(jìn)蛋白質(zhì)從細(xì)胞質(zhì)轉(zhuǎn)位到線粒體，在線粒體外膜上發(fā)揮重要作用。研究表明，TOMM20蛋白的表達(dá)與多種癌癥密切相關(guān)，其過表達(dá)可促進(jìn)腫瘤細(xì)胞的高氧化磷酸化和低糖酵解，而下調(diào)則可通過線粒體外膜通透性和細(xì)胞色素c釋放誘導(dǎo)細(xì)胞凋亡。此外，TOMM20蛋白還與帕金森病等神經(jīng)退行性疾病有關(guān)。目前，針對(duì)TOMM20蛋白的藥物研發(fā)正在積極進(jìn)行中，包括抗體藥物和靶向抑制劑等，以期通過調(diào)控TOMM20蛋白的表達(dá)和功能，治療相關(guān)疾病。
熱銷產(chǎn)品
TOMM20 Antibody (CSB-PA618983ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Mitochondrial import receptor subunit TOM20 homolog antibody at 3μg/ml
Lane 1: Mouse brain tissue
Lane 2: Hela whole cell lysate
Lane 3: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618983ESR2HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA618983ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TOMM20 Antibodies
TOMM20 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA024046GA01HU | TOMM20 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA618983ESR2HU | TOMM20 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA167518 | TOMM20 Antibody | Human | ELISA,WB |
| CSB-PA004315 | TOMM20 Antibody | Human,Mouse,Rat | WB, ELISA |
TOMM20 Proteins
TOMM20 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618983HU CSB-EP618983HU CSB-BP618983HU CSB-MP618983HU CSB-EP618983HU-B |
Recombinant Human Mitochondrial import receptor subunit TOM20 homolog (TOMM20), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
