TNFSF18

TNFSF18，全稱為腫瘤壞死因子超家族成員18，也被稱為GITRL或GITR Ligand。該蛋白在免疫調(diào)節(jié)、腫瘤發(fā)生及多種疾病進(jìn)程中扮演重要角色。TNFSF18主要表達(dá)于抗原呈遞細(xì)胞表面，通過與GITR受體結(jié)合，調(diào)節(jié)T細(xì)胞的活化和增殖，增強免疫應(yīng)答。它在惡性胸膜間皮瘤、非小細(xì)胞肺癌等多種疾病中高表達(dá)，與腫瘤的進(jìn)展和不良預(yù)后相關(guān)。目前，針對TNFSF18的藥物研發(fā)主要集中在開發(fā)抑制劑和單克隆抗體，以阻斷其信號通路，抑制腫瘤細(xì)胞生長，增強機(jī)體抗腫瘤免疫反應(yīng)。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active) (CSB-MP891791HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18 at 2 μg/ml can bind TNFSF18 (CSB-MP891791HU), the EC₅₀ is 2.565 to 2.940 ng/ml.

Activity
Human TNFRSF18 protein hFc tag (CSB-MP896537HU) captured on COOH chip can bind Human TNFSF18 protein hFc and Flag tag (CSB-MP891791HU) with an affinity constant of 38.5 nM as detected by LSPR Assay.

TNFSF18 Antibody (CSB-PA891791ESR1HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA891791ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA891791ESR1HU at dilution of 1:100

TNFSF18 Antibody

TNFSF18 Protein

TNFSF18 ELISA Kit

TNFSF18 Antibodies

TNFSF18 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA891791ESR1HU	TNFSF18 Antibody	Human	ELISA, IHC

TNFSF18 Proteins

TNFSF18 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP749268MO CSB-EP749268MO CSB-BP749268MO CSB-MP749268MO CSB-EP749268MO-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 18 (Tnfsf18), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFSF18 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP891791HU CSB-EP891791HU CSB-BP891791HU CSB-EP891791HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP002351HU	Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18), partial (Active)	E.Coli
CSB-MP891791HU	Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active)	Mammalian cell