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TNFSF10

TNFSF10(腫瘤壞死因子超家族成員10)又稱TRAIL(腫瘤壞死因子相關(guān)凋亡誘導(dǎo)配體),是一種Ⅱ型跨膜蛋白,其可溶性形式通過(guò)激活死亡受體DR4和DR5觸發(fā)細(xì)胞凋亡。TNFSF10在免疫監(jiān)視中起關(guān)鍵作用,可選擇性誘導(dǎo)癌細(xì)胞凋亡而不損傷正常組織,這一特性使其成為腫瘤治療的熱點(diǎn)靶點(diǎn)。其作用涉及線粒體途徑和Caspase蛋白酶級(jí)聯(lián)反應(yīng),同時(shí)受凋亡抑制蛋白c-FLIP和Bcl-2家族調(diào)控。
TRAIL在肝癌、肺癌等多種惡性腫瘤中表達(dá)異常,其信號(hào)通路失調(diào)與腫瘤耐藥密切相關(guān)。近年來(lái),針對(duì)TRAIL受體的單克隆抗體如Conatumumab、Lexatumumab已進(jìn)入臨床試驗(yàn),但單藥療效有限,現(xiàn)多探索與化療或靶向藥的聯(lián)合應(yīng)用。另有研究揭示TRAIL在阿爾茨海默病中可能通過(guò)清除異常蛋白沉積發(fā)揮保護(hù)作用,但過(guò)度激活也可能導(dǎo)致神經(jīng)元損傷。目前新型融合蛋白如TRAIL-Fc和三特異性抗體正在開(kāi)發(fā)中,旨在提高受體結(jié)合特異性和克服耐藥性瓶頸。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (Active) (CSB-EP023985HU1a0)

驗(yàn)證數(shù)據(jù)

CSB-EP023985HU1a0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP023985HU1a0

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF10 at 4 μg/ml can bind Human TNFRSF10B (CSB-MP023965HU1d9). The EC50 is 3.897-5.215 ng/mL.

Recombinant Human Tumor necrosis factor ligand superfamily member 10 (TNFSF10), partial (CSB-EP023985HU)

驗(yàn)證數(shù)據(jù)

CSB-EP023985HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TNFSF10 Antibody (CSB-PA07475A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA07475A0Rb

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA07475A0Rb at dilution of 1:100

CSB-PA07475A0Rb

Immunofluorescence staining of A549 cells with CSB-PA07475A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

TNFSF10 Antibodies

TNFSF10 for Homo sapiens (Human)

TNFSF10 Proteins

TNFSF10 Proteins for Mus musculus (Mouse)

TNFSF10 Proteins for Homo sapiens (Human)

TNFSF10 ELISA Kit

TNFSF10 ELISA Kit for Homo sapiens (Human)

TNFSF10 ELISA Kit for Mus musculus (Mouse)

TNFSF10 ELISA Kit for Rattus norvegicus (Rat)



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