TMEFF2（Transmembrane Protein with EGF-like and Two Follistatin-like domains 2）是一種跨膜蛋白，在人類(lèi)組織中廣泛表達(dá)。其結(jié)構(gòu)包括一個(gè)信號(hào)肽、一個(gè)EGF樣結(jié)構(gòu)域和兩個(gè)Follistatin樣結(jié)構(gòu)域。TMEFF2在多種生理和病理過(guò)程中發(fā)揮重要作用，包括胚胎發(fā)育、神經(jīng)發(fā)育、神經(jīng)保護(hù)和腫瘤發(fā)生等。

研究表明，TMEFF2在多種癌癥中具有不同的作用。例如，在乳腺癌、前列腺癌和肺癌等多種腫瘤中，TMEFF2的表達(dá)水平明顯降低，與腫瘤發(fā)生和進(jìn)展密切相關(guān)。另外，一些研究表明TMEFF2可能具有抗腫瘤的作用，例如在胃癌中表達(dá)TMEFF2的患者存活期更長(zhǎng)。因此，TMEFF2被認(rèn)為是一個(gè)重要的癌癥治療靶點(diǎn)，對(duì)其研究和開(kāi)發(fā)相關(guān)藥物具有重要意義。

更多TMEFF2相關(guān)閱讀：表皮生長(zhǎng)因子TMEFF2：腫瘤特異性或甲基化標(biāo)志物，雙功能靶點(diǎn)蘊(yùn)藏新機(jī)會(huì)!

熱銷(xiāo)產(chǎn)品

Recombinant Human TMEFF2, partial (Active) CSB-MP883439HU

驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

The purity was greater than 95% as determined by SDS-PAGE.

Excellent Bioactivity Validated by Functional ELISA

Immobilized Human TMEFF2 at 2 μg/mL can bind Anti-TMEFF2 recombinant antibody (CSB-RA883439MA1HU), the EC₅₀ is 2.129-2.956 ng/mL.

Recombinant Macaca fascicularis Jacalin-type lectin domain-containing protein (Active) CSB-MP4727MOV

驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ZG16B at 2μg/mL can bind Anti-ZG16B recombinant antibody (CSB-RA836195MA1HU)， the EC₅₀ is 20.15-28.98 ng/mL.