TMED4
TMED4，即跨膜p24運(yùn)輸?shù)鞍?。別名HNLF、ERS25、p24a3。TMED4在多種細(xì)胞過(guò)程中發(fā)揮作用，包括內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)、熱休克反應(yīng)、細(xì)胞凋亡以及囊泡蛋白運(yùn)輸，主要在早期分泌途徑中。
TMED4的作用機(jī)制涉及內(nèi)質(zhì)網(wǎng)應(yīng)激(ERS)的調(diào)節(jié)，通過(guò)IRE1α-XBP1信號(hào)通路和NRF2相關(guān)的抗氧化反應(yīng)，促進(jìn)調(diào)節(jié)性T細(xì)胞(Treg)中活性氧(ROS)的穩(wěn)態(tài)，維持Treg細(xì)胞Foxp3的表達(dá)及抑制功能。TMED4對(duì)于維持Treg細(xì)胞的穩(wěn)定性和功能至關(guān)重要，其缺失會(huì)導(dǎo)致Treg細(xì)胞中Foxp3穩(wěn)定性降低，影響Treg細(xì)胞的抑制功能，進(jìn)而可能導(dǎo)致T細(xì)胞過(guò)度激活和炎癥反應(yīng)加劇。TMED4還可能通過(guò)ER相關(guān)的降解(ERAD)系統(tǒng)抑制IRE1α的蛋白酶體降解。TMED4的功能異常與多種疾病相關(guān)，包括神經(jīng)細(xì)胞脂褐素沉積癥8型。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-5: HepG2 cells, K562 cells, Hela cells, A549 cells, Mouse intestines tissue,Primary antibody: CSB-PA639635(TMED4 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
TMED4 Antibodies
TMED4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023660GA01HU | TMED4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA639635 | TMED4 Antibody | Human,Mouse | ELISA,WB,IHC |
TMED4 Proteins
TMED4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP770365HU CSB-EP770365HU CSB-BP770365HU CSB-MP770365HU CSB-EP770365HU-B |
Recombinant Human Transmembrane emp24 domain-containing protein 4 (TMED4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
