TMED10
TMED10，即跨膜p24運(yùn)輸?shù)鞍?0，別名p23、TMP21、p24d1、S31I125、Tmp-21-I、S31III125、P24(DELTA)等。TMED10由人類TMED10基因編碼，屬于EMP24/GP25L/p24家族，是一種具有GOLD結(jié)構(gòu)域的I型膜蛋白。TMED10定位于質(zhì)膜和高爾基體池，并參與囊泡蛋白運(yùn)輸。此外，TMED10也是異聚分泌酶復(fù)合體的成員，能夠調(diào)節(jié)復(fù)合體的γ-分泌酶活性而不會(huì)影響其ε-分泌酶活性。TMED10通過形成同源寡聚體調(diào)控一系列非經(jīng)典分泌蛋白進(jìn)入內(nèi)質(zhì)網(wǎng)-高爾基體中間體（ERGIC），這條途徑被稱為TMED10通道化的非經(jīng)典分泌（THU），在調(diào)控IL-33分泌、維護(hù)腸穩(wěn)態(tài)和神經(jīng)穩(wěn)態(tài)中發(fā)揮作用。TMED10的突變與早發(fā)性家族性阿爾茨海默病有關(guān)。
熱銷產(chǎn)品
TMED10 Antibody (CSB-PA023655ESR2HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: TMED10 antibody at 4.88µg/ml
Lane 1: Hela whole cell lysate
Lane 2: Mouse liver tissue
Lane 3: Mouse lung tissue
Lane 4: 293T whole cell lysate
Lane 5: NIH/3T3 whole cell lysate
Lane 6: U87 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25 kDa
Observed band size: 25 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023655ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023655ESR2HU at dilution of 1:100
TMED10 Antibodies
TMED10 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023655GA01HU | TMED10 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA023655ESR2HU | TMED10 Antibody | Human, Mouse | ELISA, WB, IHC |
TMED10 Proteins
TMED10 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023655HU1 CSB-EP023655HU1 CSB-BP023655HU1 CSB-MP023655HU1 CSB-EP023655HU1-B |
Recombinant Human Transmembrane emp24 domain-containing protein 10 (TMED10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023655HU | Recombinant Human Transmembrane emp24 domain-containing protein 10 (TMED10) | in vitro E.coli expression system |
