TLR8，即Toll樣受體8，別名Toll樣蛋白8。它是一種在人體中由TLR8基因編碼的蛋白質(zhì)，屬于Toll樣受體家族成員之一，主要在髓樣細(xì)胞如單核細(xì)胞、樹(shù)突細(xì)胞和某些上皮細(xì)胞中表達(dá)。TLR8的作用機(jī)制是通過(guò)識(shí)別病原體相關(guān)分子模式，如某些細(xì)菌和病毒的核酸成分，激活下游的信號(hào)傳導(dǎo)途徑。TLR8的激活通常依賴(lài)于MyD88介導(dǎo)的信號(hào)通路，進(jìn)而激活NF-κB、MAPK等轉(zhuǎn)錄因子，導(dǎo)致炎癥介質(zhì)和細(xì)胞因子的釋放，從而在先天性免疫和適應(yīng)性免疫中發(fā)揮關(guān)鍵作用 。TLR8在生物學(xué)上的意義非常廣泛，它參與調(diào)節(jié)多種免疫細(xì)胞的活化、增殖和分化過(guò)程。TLR8的激活可以促進(jìn)樹(shù)突細(xì)胞成熟，增強(qiáng)其抗原呈遞能力，從而激活T細(xì)胞介導(dǎo)的免疫應(yīng)答。此外，TLR8的信號(hào)傳導(dǎo)還與炎癥反應(yīng)、細(xì)胞存活和增殖等生理過(guò)程密切相關(guān)。TLR8的功能異常與多種疾病有關(guān)，包括自身免疫性疾病、慢性炎癥性疾病和某些感染性疾病。因此，TLR8是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn) 。

熱銷(xiāo)產(chǎn)品

Recombinant Human Toll-like receptor 8 (TLR8), partial (CSB-YP023607HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of TLR8 was greater than 90% as determined by SEC-HPLC

TLR8 Antibody (CSB-PA261777)

驗(yàn)證數(shù)據(jù)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA261777(TLR8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA261777(TLR8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)