TIGAR

TIGAR，即TP53誘導的糖酵解和凋亡調(diào)節(jié)劑，別名FR2BP、C12orf5。它是一種在細胞對p53相關應激反應中起重要作用的蛋白，由人體細胞自身的基因編碼。TIGAR的作用機制主要是通過抑制糖酵解途徑，增加磷酸戊糖途徑的流量，從而產(chǎn)生更多的NADPH，以促進DNA修復和減少細胞內(nèi)活性氧(ROS)的產(chǎn)生，保護細胞免受氧化應激引起的損傷。TIGAR在生物學上的意義非常廣泛，它參與調(diào)節(jié)細胞的代謝、氧化還原平衡、細胞周期、細胞凋亡以及自噬等過程。TIGAR的表達與多種疾病的發(fā)生發(fā)展密切相關，尤其是在腫瘤發(fā)展中，TIGAR通過抗氧化作用和調(diào)節(jié)自噬，有助于腫瘤細胞逃避免疫監(jiān)視和增強腫瘤細胞的侵襲能力。此外，TIGAR的功能異常還與某些心血管疾病和神經(jīng)退行性疾病相關。因此，TIGAR是藥物開發(fā)和疾病治療中的一個潛在靶點。

熱銷產(chǎn)品

Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (TIGAR) (CSB-AP000111HU)

驗證數(shù)據(jù)

TIGAR Antibody (CSB-PA889078LA01HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889078LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA889078LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA889078LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TIGAR Antibody

TIGAR Protein

TIGAR Antibodies

TIGAR for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA202764	TIGAR Antibody	Human	ELISA,IHC
CSB-PA162542	TIGAR Antibody	Human	ELISA,WB,IHC
CSB-PA889078LA01HU	TIGAR Antibody	Human	ELISA, IHC, IF
CSB-PA889078LC01HU	TIGAR Antibody, FITC conjugated	Human
CSB-PA889078LD01HU	TIGAR Antibody, Biotin conjugated	Human	ELISA

TIGAR Proteins

TIGAR Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP889078HU CSB-EP889078HU CSB-BP889078HU CSB-MP889078HU CSB-EP889078HU-B	Recombinant Human Probable fructose-2,6-bisphosphatase TIGAR (TIGAR)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP000111HU	Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (TIGAR)	E.Coli