TACR1

TACR1，全稱(chēng)為T(mén)achykinin receptor 1，是一種神經(jīng)激肽受體，也被稱(chēng)為NK1R或SPR。該受體主要分布于中樞和外周神經(jīng)系統(tǒng)，能夠與多種神經(jīng)肽物質(zhì)結(jié)合，如緩激肽和激肽素等，參與多種生理過(guò)程的調(diào)節(jié)。TACR1與多種蛋白質(zhì)相互作用，在炎癥和其他疾病的發(fā)生發(fā)展中發(fā)揮著重要作用。例如，TACR1激動(dòng)劑對(duì)治療精神分裂癥、抑郁癥和藥物成癮具有潛力。近年來(lái)，科學(xué)家們通過(guò)結(jié)構(gòu)生物學(xué)研究手段揭示了TAAR1與藥物成癮和神經(jīng)精神疾病相關(guān)的分子識(shí)別機(jī)制，為治療藥物成癮和研發(fā)新型抗精神類(lèi)藥物提供了重要的理論基礎(chǔ)。此外，TAAR1也被認(rèn)為與多種精神疾病相關(guān)，如精神分裂癥、注意力缺陷多動(dòng)癥等。針對(duì)TAAR1開(kāi)發(fā)的新型藥物，如TAAR1小分子激動(dòng)劑ZH8651，已在動(dòng)物模型中驗(yàn)證了其改善精神分裂癥的作用，為相關(guān)疾病的治療提供了新的思路和途徑。

熱銷(xiāo)產(chǎn)品

Recombinant Human Substance-P receptor (TACR1), partial (CSB-EP023068HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TACR1 Recombinant Monoclonal Antibody (CSB-RA555508A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: THP-1 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Ntera-2 whole cell lysate, Mouse Brain whole cell lysate
All lanes: TACR1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 36 kDa
Observed band size: 50 kDa

TACR1 Antibody (CSB-PA09674A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA09674A0Rb at dilution of 1:100

Immunofluorescent analysis of NIH/3T3 cells using CSB-PA09674A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

TACR1 Antibody

TACR1 Protein

TACR1 ELISA Kit

TACR1 Antibodies

TACR1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA09674A0Rb	TACR1 Antibody	Human	ELISA, IHC, IF
CSB-PA09674C0Rb	TACR1 Antibody, FITC conjugated	Human
CSB-PA09674D0Rb	TACR1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA023068GA01HU	TACR1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA050201	TACR1 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-RA555508A0HU	TACR1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB

TACR1 Proteins

TACR1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP023068RA1 CSB-EP023068RA1 CSB-BP023068RA1 CSB-MP023068RA1 CSB-EP023068RA1-B	Recombinant Rat Substance-P receptor (Tacr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023068RA	Recombinant Rat Substance-P receptor (Tacr1)	in vitro E.coli expression system

TACR1 Proteins for Cavia porcellus (Guinea pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP023068GU1 CSB-EP023068GU1 CSB-BP023068GU1 CSB-MP023068GU1 CSB-EP023068GU1-B	Recombinant Guinea pig Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023068GU	Recombinant Guinea pig Substance-P receptor (TACR1)	in vitro E.coli expression system

TACR1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP023068HU CSB-BP023068HU CSB-MP023068HU CSB-EP023068HU-B	Recombinant Human Substance-P receptor (TACR1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023068HU	Recombinant Human Substance-P receptor (TACR1), partial	E.coli

TACR1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP023068MO1 CSB-EP023068MO1 CSB-BP023068MO1 CSB-MP023068MO1 CSB-EP023068MO1-B	Recombinant Mouse Substance-P receptor (Tacr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023068MO	Recombinant Mouse Substance-P receptor (Tacr1)	in vitro E.coli expression system

TACR1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP688584DO1 CSB-EP688584DO1 CSB-BP688584DO1 CSB-MP688584DO1 CSB-EP688584DO1-B	Recombinant Dog Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF688584DO	Recombinant Dog Substance-P receptor (TACR1)	in vitro E.coli expression system

TACR1 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP710711MRA1 CSB-EP710711MRA1 CSB-BP710711MRA1 CSB-MP710711MRA1 CSB-EP710711MRA1-B	Recombinant Meriones unguiculatus Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF710711MRA	Recombinant Meriones unguiculatus Substance-P receptor (TACR1)	in vitro E.coli expression system

TACR1 Proteins for Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP839654LQA1 CSB-EP839654LQA1 CSB-BP839654LQA1 CSB-MP839654LQA1 CSB-EP839654LQA1-B	Recombinant Lithobates catesbeiana Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF839654LQA	Recombinant Lithobates catesbeiana Substance-P receptor (TACR1)	in vitro E.coli expression system