TACC2
TACC2，全稱為 Transforming acidic coiled-coil containing protein 2，別名包括 AZU-1 和 ECTACC。該蛋白參與細(xì)胞分裂和維持基因組穩(wěn)定性的過程，在中心體-微管動(dòng)力學(xué)中起著重要作用。TACC2 蛋白與微管結(jié)合蛋白相互作用，影響紡錘體形成和染色體分離，從而確保細(xì)胞分裂的正常進(jìn)行。TACC2 蛋白在多種組織中表達(dá)，尤其在腦、睪丸和乳腺中表達(dá)較高，提示其可能參與神經(jīng)發(fā)育和生殖系統(tǒng)功能。突變或表達(dá)異常的 TACC2 蛋白可能導(dǎo)致功能紊亂，與某些癌癥（如乳腺癌、膠質(zhì)瘤）的發(fā)生相關(guān)。研究還發(fā)現(xiàn) TACC2 蛋白通過 EGFR/ERK 信號(hào)通路影響細(xì)胞遷移，其異常表達(dá)可能促進(jìn)腫瘤轉(zhuǎn)移。在疾病關(guān)聯(lián)方面，TACC2 蛋白的突變或表達(dá)失調(diào)與精神分裂癥、自閉癥譜系障礙等神經(jīng)發(fā)育疾病有關(guān)，也可能參與激素依賴性癌癥的進(jìn)展。目前，針對(duì) TACC2 蛋白的藥物研發(fā)尚處于早期階段，但已有研究表明，靶向 TACC2 蛋白的藥物可能對(duì)某些癌癥的治療具有潛在價(jià)值。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA633214(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA633214(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: CSB-PA633214(TACC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
TACC2 Antibodies
TACC2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023066GA01HU | TACC2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA633214 | TACC2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA235316 | TACC2 Antibody | Human,Mouse | ELISA,IHC |
TACC2 Proteins
TACC2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023066HU CSB-EP023066HU CSB-BP023066HU CSB-MP023066HU CSB-EP023066HU-B |
Recombinant Human Transforming acidic coiled-coil-containing protein 2 (TACC2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
