SPI1
SPI1，即SIP1蛋白，別名PU.1、Spi-1。它是一種由人類SPI1基因編碼的轉(zhuǎn)錄因子，屬于ETS家族成員之一。SPI1在多種細胞類型中表達，尤其在髓系和淋巴系細胞的發(fā)育中起著關鍵作用。其作用機制涉及與DNA結合，調(diào)節(jié)下游基因的表達，影響細胞的增殖、分化和存活。SPI1在中樞神經(jīng)系統(tǒng)中，可以影響小膠質(zhì)細胞轉(zhuǎn)錄組和表型改變，調(diào)節(jié)神經(jīng)炎癥反應。此外，SPI1還參與腫瘤微環(huán)境中的有氧糖酵解，促進腫瘤細胞的代謝和侵襲性。SPI1的異常表達與多種疾病相關，包括腦出血、阿爾茨海默病、某些類型的癌癥等，使其成為潛在的治療靶點。
熱銷產(chǎn)品
Recombinant Human Transcription factor PU.1 (SPI1) (CSB-EP022567HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022567HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPI1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022567HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPI1.
驗證數(shù)據(jù)
Western blot analysis of extracts from HepG2 and 293 cells, using SPI1 antibody.
SPI1 Antibodies
SPI1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA16619C0Rb | SPI1 Antibody, FITC conjugated | Human | |
| CSB-PA16619B0Rb | SPI1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA16619A0Rb | SPI1 Antibody | Human | ELISA |
| CSB-PA022567GA01HU | SPI1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA580989 | SPI1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003887 | SPI1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
SPI1 Proteins
SPI1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022567MO CSB-BP022567MO CSB-MP022567MO CSB-EP022567MO-B |
Recombinant Mouse Transcription factor PU.1 (Spi1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPI1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022567HU CSB-MP022567HU |
Recombinant Human Transcription factor PU.1 (SPI1) | Yeast Mammalian cell |
| CSB-EP022567HU | Recombinant Human Transcription factor PU.1 (SPI1) | E.coli |
SPI1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP340209SVG CSB-EP340209SVG CSB-BP340209SVG CSB-MP340209SVG CSB-EP340209SVG-B |
Recombinant Saccharomyces cerevisiae Uncharacterized cell wall protein SPI1 (SPI1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPI1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP341006SXV CSB-EP341006SXV CSB-BP341006SXV CSB-MP341006SXV CSB-EP341006SXV-B |
Recombinant Schizosaccharomyces pombe GTP-binding nuclear protein spi1 (spi1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPI1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP721513RA CSB-EP721513RA CSB-BP721513RA CSB-MP721513RA CSB-EP721513RA-B |
Recombinant Rat Transcription factor PU.1 (Spi1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPI1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP757662PI CSB-EP757662PI CSB-BP757662PI CSB-MP757662PI CSB-EP757662PI-B |
Recombinant Pig Transcription factor PU.1 (SPI1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
