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SPA17

SPA17全稱為精子發(fā)生相關(guān)蛋白17,也被稱為SP17或CT37,最初在男性生殖細(xì)胞中被發(fā)現(xiàn),主要參與精子形成及受精過(guò)程中的透明帶結(jié)合。SPA17在卵巢癌、肺癌、多發(fā)性骨髓瘤等多種惡性腫瘤中異常高表達(dá),通過(guò)增強(qiáng)細(xì)胞遷移能力和促進(jìn)血管生成參與腫瘤進(jìn)展。其分子機(jī)制涉及調(diào)控細(xì)胞外基質(zhì)重塑相關(guān)蛋白水解酶活性,并與整合素信號(hào)網(wǎng)絡(luò)形成交互作用,可能影響腫瘤細(xì)胞對(duì)微環(huán)境的適應(yīng)性。目前針對(duì)SPA17的抗體藥物及多肽疫苗已進(jìn)入臨床前研究階段,特別是在卵巢癌治療領(lǐng)域,利用其腫瘤特異性表達(dá)的免疫治療策略展現(xiàn)出潛力。有研究發(fā)現(xiàn)靶向SPA17的CAR-T細(xì)胞療法在動(dòng)物實(shí)驗(yàn)中成功抑制了腫瘤轉(zhuǎn)移,同時(shí)被證實(shí)與免疫逃逸相關(guān),其阻斷劑可能成為聯(lián)合PD-1抑制劑的新型治療方案。

熱銷產(chǎn)品

Recombinant Human Sperm surface protein Sp17 (SPA17), partial (CSB-EP614892HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP614892HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP614892HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.

CSB-EP614892HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.

SPA17 Antibody (CSB-PA12124A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA12124A0Rb

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA12124A0Rb

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

SPA17 Antibodies

SPA17 for Homo sapiens (Human)

SPA17 Proteins

SPA17 Proteins for Homo sapiens (Human)



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