SLC7A5
SLC7A5全稱為溶質(zhì)載體家族7成員5（Solute Carrier Family 7 Member 5），也被稱為L型氨基酸轉(zhuǎn)運蛋白1（LAT1）或CD98輕鏈。SLC7A5主要通過與SLC3A2（CD98重鏈）結(jié)合形成異源二聚體，負(fù)責(zé)轉(zhuǎn)運細(xì)胞必需的中性氨基酸如亮氨酸、苯丙氨酸等，其活性與細(xì)胞增殖、代謝調(diào)控密切相關(guān)。LAT1在多種惡性腫瘤中異常高表達(dá)，通過激活mTORC1信號網(wǎng)絡(luò)促進(jìn)腫瘤生長、侵襲及化療耐藥，尤其在膠質(zhì)瘤、乳腺癌和結(jié)直腸癌中成為預(yù)后不良的標(biāo)志物。近年來針對LAT1的小分子抑制劑開發(fā)進(jìn)展顯著，例如JPH203已在肝癌和胰腺癌模型中顯示抗腫瘤效果，KYT-0353等候選藥物也進(jìn)入臨床前研究階段。SLC7A5與血腦屏障的氨基酸運輸功能關(guān)聯(lián)，其異常表達(dá)還可能參與神經(jīng)系統(tǒng)疾病如癲癇的病理過程。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLC7A5 Antibody (CSB-PA068714)
驗證數(shù)據(jù)
Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA068714(SLC7A5 Antibody) at dilution 1/300 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
SLC7A5 Antibodies
SLC7A5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA021717GA01HU | SLC7A5 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA068714 | SLC7A5 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA057466 | SLC7A5 Antibody | Human | ELISA,WB |
| CSB-PA157177 | SLC7A5 Antibody | Human | ELISA,WB |
SLC7A5 Proteins
SLC7A5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021717HU CSB-BP021717HU CSB-MP021717HU CSB-EP021717HU-B |
Recombinant Human Large neutral amino acids transporter small subunit 1 (SLC7A5), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP021717HU | Recombinant Human Large neutral amino acids transporter small subunit 1 (SLC7A5), partial | E.coli |
| CSB-MP021717HU(A4) | Recombinant Human Large neutral amino acids transporter small subunit 1 (SLC7A5)-VLPs | Mammalian cell |
SLC7A5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP717351RA CSB-EP717351RA CSB-BP717351RA CSB-MP717351RA CSB-EP717351RA-B |
Recombinant Rat Large neutral amino acids transporter small subunit 1 (Slc7a5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLC7A5 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP773559RB CSB-EP773559RB CSB-BP773559RB CSB-MP773559RB CSB-EP773559RB-B |
Recombinant Rabbit Large neutral amino acids transporter small subunit 1 (SLC7A5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLC7A5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP021717HUa3 | Recombinant Human Large neutral amino acids transporter small subunit 1 (SLC7A5), partial | E.coli |
