SLC30A8

SLC30A8，也被稱為鋅轉(zhuǎn)運(yùn)蛋白8。該蛋白主要在胰島β細(xì)胞中表達(dá)，負(fù)責(zé)將鋅離子轉(zhuǎn)運(yùn)至胰島素分泌顆粒中，參與胰島素的合成、儲(chǔ)存和分泌過程。研究表明，ZnT8蛋白的功能失活可通過增強(qiáng)胰島素分泌預(yù)防糖尿病。例如，SLC30A8基因的罕見功能缺失等位基因p.Arg138*在芬蘭西部富集，可預(yù)防2型糖尿病。研究發(fā)現(xiàn)，該等位基因?qū)е耂LC30A8表達(dá)減少，進(jìn)而增加葡萄糖反應(yīng)性和胰島素原轉(zhuǎn)換，從而預(yù)防糖尿病。此外，ZnT8蛋白也被認(rèn)為是2型糖尿病中維持胰島素分泌能力的治療靶點(diǎn)。目前，研究人員正在探索抑制ZnT8蛋白功能的藥物，以預(yù)防或治療2型糖尿病。

熱銷產(chǎn)品

Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8) (CSB-CF818247HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC30A8 Antibody (CSB-PA818247LA01HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA818247LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA818247LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

SLC30A8 Antibody

SLC30A8 Protein

SLC30A8 ELISA Kit

SLC30A8 Antibodies

SLC30A8 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA021573GA01HU	SLC30A8 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007754	SLC30A8 Antibody	Human	WB, ELISA
CSB-PA818247LA01HU	SLC30A8 Antibody	Human	ELISA, IHC, IF
CSB-PA818247LC01HU	SLC30A8 Antibody, FITC conjugated	Human
CSB-PA818247LD01HU	SLC30A8 Antibody, Biotin conjugated	Human	ELISA

SLC30A8 Proteins

SLC30A8 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP818247HU1 CSB-BP818247HU1 CSB-MP818247HU1 CSB-EP818247HU1-B	Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF818247HU	Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8)	in vitro E.coli expression system
CSB-MP818247HU	Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8)-VLPs	Mammalian cell
CSB-EP818247HU1	Recombinant Human Proton-coupled zinc antiporter SLC30A8 (SLC30A8), partial	E.coli