SETD2
SETD2，全稱為SET domain containing 2，是一種重要的表觀遺傳修飾酶，屬于SET基因家族。該蛋白具有甲基轉(zhuǎn)移酶活性，主要通過修飾組蛋白H3K36的甲基化來(lái)影響基因表達(dá)，進(jìn)而參與多種生理過程。SETD2蛋白在巨核細(xì)胞發(fā)育和血小板生成中發(fā)揮著關(guān)鍵作用，其缺失或突變會(huì)導(dǎo)致巨核細(xì)胞多倍體化異常，進(jìn)而影響血小板數(shù)量和功能。此外，SETD2蛋白還與多種疾病相關(guān)，如癌癥、心血管疾病和肺動(dòng)脈高壓等。在藥物研發(fā)方面，已有研究表明SETD2蛋白可作為潛在的靶點(diǎn)，例如口服SETD2抑制劑EZM0414已被FDA授予快速通道資格，用于治療復(fù)發(fā)性或難治性彌漫性大B細(xì)胞淋巴瘤。SETD2蛋白的研究為深入理解相關(guān)疾病的發(fā)生機(jī)制和開發(fā)新型藥物提供了重要線索。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA028785(SETD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA028785(SETD2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
SETD2 Antibodies
SETD2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA028785 | SETD2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA458397 | SETD2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA871619XA01phHU | SETD2 Antibody | Human | ELISA |
SETD2 Proteins
SETD2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP871619HU CSB-EP871619HU CSB-BP871619HU CSB-MP871619HU CSB-EP871619HU-B |
Recombinant Human Histone-lysine N-methyltransferase SETD2 (SETD2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
