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SELPLG

SELPLG,即選擇素P配體,別名CLA、CD162、PSGL1、PSGL-1,是一種由人類(lèi)SELPLG基因編碼的糖蛋白,主要在骨髓細(xì)胞和受刺激的T淋巴細(xì)胞上表達(dá)。
SELPLG通過(guò)作為P-、E-和L-選擇素的高親和力反受體,介導(dǎo)白細(xì)胞與活化的血小板或表達(dá)選擇素的內(nèi)皮細(xì)胞的粘附,這一過(guò)程對(duì)于炎癥期間白細(xì)胞的運(yùn)輸至關(guān)重要。SELPLG需要經(jīng)過(guò)酪氨酸硫酸化和O-連接的聚糖添加唾液酸Lewis x四糖(sLex)的翻譯后修飾,以實(shí)現(xiàn)其高親和力結(jié)合活性。SELPLG在先天性和適應(yīng)性免疫反應(yīng)中發(fā)揮關(guān)鍵作用,其異常表達(dá)和基因多態(tài)性與免疫反應(yīng)的缺陷有關(guān)。

熱銷(xiāo)產(chǎn)品

Recombinant Human P-selectin glycoprotein ligand 1 (SELPLG), partial (Active) (CSB-MP621767HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP621767HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP621767HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SELPLG at 2 μg/ml can bind Anti-SELPLG recombinant antibody (CSB-RA621767MA1HU). The EC50 is 2.420-2.733 ng/mL.

SELPLG Recombinant Monoclonal Antibody (CSB-RA567010A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA567010A0HU

IHC image of CSB-RA567010A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

SELPLG Antibodies

SELPLG for Homo sapiens (Human)

SELPLG Proteins

SELPLG Proteins for Homo sapiens (Human)

SELPLG Proteins for Mus musculus (Mouse)



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