日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

SCAP

SCAP is a protein in humans that is encoded by SCAP gene. Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

SCAP Antibodies

SCAP for Homo sapiens (Human)

SCAP Proteins

SCAP Proteins for Rattus norvegicus (Rat)

SCAP Proteins for Bos taurus (Bovine)

SCAP Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

SCAP Proteins for Xenopus laevis (African clawed frog)

SCAP Proteins for Homo sapiens (Human)

SCAP Proteins for Sus scrofa (Pig)

SCAP Proteins for Mus musculus (Mouse)



×