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ROR1

ROR1,全稱受體酪氨酸激酶樣孤兒受體1,常見別名包括Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1)等。該蛋白在正常組織中低表達(dá)或不表達(dá),但在多種惡性腫瘤中高表達(dá),如慢性淋巴細(xì)胞白血病、乳腺癌、卵巢癌、黑色素瘤、肺腺癌等。ROR1蛋白屬于I型膜蛋白,具有酪氨酸激酶活性,參與細(xì)胞增殖、分化、遷移等過(guò)程。研究表明,ROR1蛋白與腫瘤細(xì)胞的生長(zhǎng)和轉(zhuǎn)移密切相關(guān),是腫瘤治療的重要靶點(diǎn)。目前,針對(duì)ROR1蛋白的藥物研發(fā)正在積極進(jìn)行中,包括抗體偶聯(lián)藥物(ADC)、單克隆抗體、雙特異性抗體以及CAR-T療法等多種類型。其中,華東醫(yī)藥研發(fā)的ROR1 ADC創(chuàng)新藥注射用HDM2005已獲得美國(guó)FDA孤兒藥資格認(rèn)定,顯示出良好的臨床前景。此外,石藥集團(tuán)、默沙東等藥企也在積極布局ROR1靶點(diǎn)藥物的研發(fā),預(yù)計(jì)未來(lái)將有更多療效顯著、安全性高的ROR1靶向藥物面世,為腫瘤患者帶來(lái)新的治療選擇。

熱銷產(chǎn)品

Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial (Active) (CSB-MP020067HU1d7)

驗(yàn)證數(shù)據(jù)

CSB-MP020067HU1d7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP020067HU1d7

Activity
Measured by its binding ability in a functional ELISA. Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody(CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.

CSB-MP020067HU1d7

The purity of ROR1 was greater than 90% as determined by SEC-HPLC

CSB-MP020067HU1d7

ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU) captured on Protein A Chip can bind Recombinant Human ROR1 protein with an affinity constant of 0.305 nM as detected by MetaSPR Assay (WeSPRTM 200).

ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA020067A1HU

The Binding Activity of ROR1 with Anti-ROR1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ROR1(CSB-MP020067HU1d7) at 2 μg/mL can bind Anti-ROR1 recombinant antibody, the EC50 is 0.2450-0.3416 ng/mL.

CSB-RA020067A1HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

ROR1 Antibody (CSB-PA020067LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA020067LA01HU

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA020067LA01HU at dilution of 1:10

ROR1 Antibodies

ROR1 for Homo sapiens (Human)

ROR1 Proteins

ROR1 Proteins for Homo sapiens (Human)



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