ROBO4
ROBO4，全稱(chēng)為Roundabout homolog 4，別名包括MRB、AOVD3和ECSM4。該蛋白主要表達(dá)于內(nèi)皮細(xì)胞，參與血管生成和內(nèi)皮屏障的建立，并位于細(xì)胞外外體泡中。ROBO4與主動(dòng)脈瓣疾病3相關(guān)，其突變可能導(dǎo)致主動(dòng)脈瓣畸形、狹窄和升主動(dòng)脈瘤等病癥。此外，ROBO4還參與調(diào)控心臟系統(tǒng)靜脈回流和心包膜的發(fā)育，其缺失會(huì)導(dǎo)致小鼠發(fā)育過(guò)程中的腎臟缺失和輸尿管發(fā)育不全。ROBO4蛋白通過(guò)與SLIT2蛋白結(jié)合，發(fā)揮抑制細(xì)胞間粘附介導(dǎo)活性的作用，從而穩(wěn)定血管通透性和完整性。目前，針對(duì)ROBO4蛋白的藥物研發(fā)尚處于探索階段，但其在心血管疾病和腎臟疾病治療方面具有潛在的應(yīng)用價(jià)值。
熱銷(xiāo)產(chǎn)品
Recombinant Human Roundabout homolog 4 (ROBO4),?partial (CSB-EP845177HU1d7)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Human Roundabout homolog 4(ROBO4) ELISA kit (CSB-EL020057HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL020057HU
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測(cè)范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ROBO4 Antibodies
ROBO4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA020057GA01HU | ROBO4 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA121728 | ROBO4 Antibody | Human | ELISA,IHC |
| CSB-PA903544 | ROBO4 Antibody | Human | ELISA,IHC |
| CSB-PA845177ESR2HU | ROBO4 Antibody | Human | ELISA, IHC |
ROBO4 Proteins
ROBO4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP845177HU CSB-EP845177HU CSB-BP845177HU CSB-MP845177HU CSB-EP845177HU-B |
Recombinant Human Roundabout homolog 4 (ROBO4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP845177HU1d7 | Recombinant Human Roundabout homolog 4 (ROBO4),?partial | E.coli |
ROBO4 ELISA Kit
ROBO4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL020057HU | Human Roundabout homolog 4(ROBO4) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates, urine | 15.6 pg/mL |
