RO60
RO60，全稱為RNA結(jié)合蛋白Ro60，也被稱為SS-A或TROVE2，是一種在動物細(xì)胞中廣泛存在的RNA結(jié)合蛋白。它通常以自由蛋白形式存在，或作為核糖核蛋白復(fù)合物的一部分，與Y RNAs等非編碼RNA結(jié)合。RO60具有環(huán)狀結(jié)構(gòu)，其外表面結(jié)合Y RNAs，而內(nèi)部腔室則可以結(jié)合錯折疊的非編碼RNA。這種結(jié)合方式有助于清除細(xì)胞內(nèi)的異常RNA分子，維持RNA穩(wěn)態(tài)。RO60蛋白在多種自身免疫性疾病中作為抗體靶點，如干燥綜合征、系統(tǒng)性紅斑狼瘡和新生兒紅斑狼瘡。此外，RO60蛋白還與胃癌的多藥耐藥性相關(guān)，研究表明其可能參與腫瘤細(xì)胞的耐藥機制。目前，針對RO60蛋白的藥物研發(fā)主要集中在免疫調(diào)節(jié)和抗腫瘤領(lǐng)域，旨在通過抑制RO60蛋白的功能來治療相關(guān)疾病。
熱銷產(chǎn)品
Recombinant Human RNA-binding protein RO60 (RO60), partial (CSB-EP025071HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TROVE2 Antibody (CSB-PA13749A0Rb)
驗證數(shù)據(jù)
Western blot
All lanes: TROVE2 antibody at 2µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA13749A0Rb at dilution of 1:20
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA13749A0Rb at dilution of 1:20
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, PC-3 whole cell lysate, Mouse heart tissue, Mouse spleen tissue, Mouse lung tissue
All lanes: TROVE2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA13749A0Rb at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA13749A0Rb at dilution of 1:100
Western Blot
Positive WB detected in: Hela whole cell lysate, Rat kidney tissue
All lanes: TROVE2 antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61, 24, 59, 60 kDa
Observed band size: 61 kDa
Immunofluorescent analysis of PC-3 cells using CSB-PA13749A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA13749A0Rb at dilution of 1:100
RO60 Antibodies
RO60 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025071GA01HU | TROVE2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA13749A0Rb | TROVE2 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| CSB-PA13749D0Rb | TROVE2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA050155 | TROVE2 Antibody | Human | WB, ELISA |
RO60 Proteins
RO60 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025071HU CSB-EP025071HU CSB-BP025071HU CSB-MP025071HU CSB-EP025071HU-B |
Recombinant Human RNA-binding protein RO60 (RO60) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025071HU1 | Recombinant Human RNA-binding protein RO60 (RO60), partial | E.coli |
