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Your Good Partner in Biology Research

RHBDF2

RHBDF2,全稱為無活性菱形因子2(Rhomoid 5 homolog 2),也被稱為RHBDL6或iRhom2。該蛋白屬于菱形絲氨酸蛋白酶家族,是一類跨膜蛋白,但缺乏蛋白水解活性。RHBDF2主要在細(xì)胞膜或內(nèi)質(zhì)網(wǎng)膜上發(fā)揮作用,通過調(diào)控底物蛋白的切割來影響信號傳導(dǎo)途徑,尤其與表皮生長因子受體(EGFR)的激活密切相關(guān)。RHBDF2的表達(dá)與組織修復(fù)、炎癥反應(yīng)和細(xì)胞增殖等過程相關(guān)。RHBDF2的突變可能導(dǎo)致TOC(Tylosis with Esophageal Cancer)綜合征,表現(xiàn)為手掌和腳底過度角化以及食管癌風(fēng)險(xiǎn)增加。此外,RHBDF2還與慢性炎癥性疾病和某些癌癥的發(fā)展相關(guān)。目前,針對RHBDF2相關(guān)疾病的研究主要集中在探索其功能異常對信號傳導(dǎo)的影響,以及開發(fā)針對RHBDF2的藥物或治療策略。

熱銷產(chǎn)品

RHBDF2 Antibody (CSB-PA744137LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA744137LA01HU

IHC image of CSB-PA744137LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA744137LA01HU

Immunofluorescence staining of A549 cells with CSB-PA744137LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RHBDF2 Antibodies

RHBDF2 for Homo sapiens (Human)

RHBDF2 Proteins

RHBDF2 Proteins for Homo sapiens (Human)



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