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RET

RET是受體酪氨酸激酶家族的一員,其結構包含細胞外域、跨膜域、酪氨酸激酶域和羧基末端。RET通過與特定配體結合,激活其胞內(nèi)區(qū)的酪氨酸激酶活性,進而啟動下游信號轉(zhuǎn)導通路,影響細胞的生長、增殖、分化和凋亡等生物學過程。RET在維持多種細胞類型如神經(jīng)細胞、內(nèi)分泌細胞和腎臟細胞的正常功能中發(fā)揮著重要作用。然而,當RET基因發(fā)生突變或異常表達時,可能導致疾病的發(fā)生,如甲狀腺髓樣癌等。因此,對RET的結構、功能和生物學作用的研究不僅有助于我們理解其在正常生理過程中的作用,也為相關疾病的預防和治療提供了新的視角和策略。

熱銷產(chǎn)品

Recombinant?Human?Proto-oncogene?tyrosine-protein?kinase?receptor?Ret?(RET),?partial (Active) (CSB-MP019572HU)

驗證數(shù)據(jù)

CSB-MP019572HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP019572HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human RET at 2 μg/ml can bind Anti-RET recombinant antibody (CSB-RA019572MA1HU). The EC50 is 1.857-2.048 ng/mL.

RET Recombinant Monoclonal Antibody (CSB-RA288083A0HU)

驗證數(shù)據(jù)

CSB-RA288083A0HU

Overlay histogram showing Hela cells stained with CSB-RA288083A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

RET Antibodies

RET for Homo sapiens (Human)

RET Proteins

RET Proteins for Homo sapiens (Human)



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