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RBPMS

RBPMS,全稱為RNA結(jié)合蛋白,是一種參與RNA加工的蛋白質(zhì)。它具有多種別名,包括HERMES、RBP-MS等。RBPMS蛋白在細(xì)胞質(zhì)中發(fā)揮作用,參與正調(diào)控SMAD蛋白信號傳導(dǎo)和氧化應(yīng)激響應(yīng)。研究表明,RBPMS蛋白可以通過促進SMAD2和SMAD3在C末端磷酸化以及SMAD蛋白的核累積來刺激SMAD介導(dǎo)的轉(zhuǎn)錄激活。此外,RBPMS蛋白還參與了心臟發(fā)育過程中轉(zhuǎn)錄后調(diào)控。在疾病方面,RBPMS蛋白與動脈粥樣硬化相關(guān)。研究發(fā)現(xiàn),RBPMS基因表達與血管平滑肌細(xì)胞收縮標(biāo)志物呈正相關(guān),其通過促進收縮表型分化顯著減少高脂飲食ApoE-/-小鼠的斑塊帽形成并抑制內(nèi)膜增生。這提示RBPMS蛋白可能通過雙重調(diào)控機制抑制血管平滑肌細(xì)胞介導(dǎo)的斑塊進展和介入后再狹窄,為相關(guān)血管疾病的治療提供了新的分子靶點。目前,針對RBPMS蛋白的藥物研發(fā)尚處于起步階段,但已有研究揭示了其在動脈粥樣硬化中的作用,為開發(fā)新型抗動脈粥樣硬化藥物提供了新的思路。

熱銷產(chǎn)品

Recombinant Human RNA-binding protein with multiple splicing (RBPMS) (CSB-EP821892HU)

驗證數(shù)據(jù)

CSB-EP821892HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP821892HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RBPMS.

CSB-EP821892HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP821892HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) RBPMS.

CSB-EP821892HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RBPMS Antibody (CSB-PA04569A0Rb)

驗證數(shù)據(jù)

CSB-PA04569A0Rb

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA04569A0Rb at dilution of 1:100

CSB-PA04569A0Rb

Immunofluorescent analysis of PC-3 cells using CSB-PA04569A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

RBPMS Antibodies

RBPMS for Homo sapiens (Human)

RBPMS Proteins

RBPMS Proteins for Homo sapiens (Human)



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