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RABGGTB

RABGGTB,全稱為Rab geranylgeranyltransferase subunit beta,也被稱為Rab蛋白異戊二烯轉(zhuǎn)移酶β亞基。該蛋白在細(xì)胞內(nèi)的膜轉(zhuǎn)運(yùn)和信號(hào)傳導(dǎo)中發(fā)揮著重要作用。RABGGTB是Rab蛋白異戊二烯轉(zhuǎn)移酶(RabGGTase)復(fù)合物的一部分,負(fù)責(zé)將異戊二烯基團(tuán)轉(zhuǎn)移到Rab蛋白上,從而激活它們并促進(jìn)其在細(xì)胞膜上的定位。這一過(guò)程對(duì)于細(xì)胞內(nèi)囊泡運(yùn)輸和膜蛋白定位至關(guān)重要。RABGGTB的表達(dá)和活性在多種生物學(xué)過(guò)程中受到嚴(yán)格調(diào)控,例如炎癥反應(yīng)和腫瘤發(fā)生。研究表明,RABGGTB在牙周炎和多發(fā)性硬化癥患者的血液中表達(dá)水平發(fā)生變化,提示其與這些疾病的發(fā)生發(fā)展密切相關(guān)。在藥物研發(fā)方面,RABGGTB被視為治療肌萎縮側(cè)索硬化癥的潛在靶點(diǎn),相關(guān)研究正在探索其作為疾病診斷和治療的新策略。

熱銷(xiāo)產(chǎn)品

RABGGTB Antibody (CSB-PA019235HA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA019235HA01HU

IHC image of CSB-PA019235HA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA019235HA01HU

Immunofluorescence staining of U251 cells with CSB-PA019235HA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RABGGTB Antibodies

RABGGTB for Homo sapiens (Human)

RABGGTB Proteins

RABGGTB Proteins for Homo sapiens (Human)



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