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PTGES3

PTGES3,全稱為前列腺素E合酶3,常用別名包括p23。它是一種多功能蛋白,常與熱休克蛋白90形成復(fù)合物,在細(xì)胞內(nèi)協(xié)助多種關(guān)鍵蛋白維持正確構(gòu)象,保障它們正常發(fā)揮生理功能。PTGES3異常表達(dá)和多種癌癥關(guān)聯(lián)緊密,比如乳腺癌、肺癌患者體內(nèi)它的含量往往升高,可能促進(jìn)腫瘤細(xì)胞生長與擴(kuò)散;此外,它在部分炎癥性疾病中也可能起到作用,影響病情進(jìn)展。目前針對該蛋白的藥物研發(fā)處于早期階段,已有一些小分子化合物被發(fā)現(xiàn)能抑制其功能,這些化合物有望成為新型抗癌或抗炎藥物的候選,不過仍需更多臨床前研究來驗證其有效性與安全性。整體來看,它是一個具有潛在臨床價值的靶點,相關(guān)研究正在逐步深入。

熱銷產(chǎn)品

Recombinant Human Prostaglandin E synthase 3 (PTGES3) (CSB-EP613587HU)

驗證數(shù)據(jù)

CSB-EP613587HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PTGES3 Recombinant Monoclonal Antibody (CSB-RA150881A0HU)

驗證數(shù)據(jù)

CSB-RA150881A0HU

Flow cytometric analysis of Prostaglandin E synthase 3 expression in HepG2 cells using Prostaglandin E synthase 3 antibody. Green, isotype control; red, Prostaglandin E synthase 3.

CSB-RA150881A0HU

Immunocytochemical staining of HepG2 cells with Prostaglandin E synthase 3 antibody. Nuclei were stained blue with DAPI; Prostaglandin E synthase 3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.

CSB-RA150881A0HU

Western blotting analysis using prostaglandin E synthase 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with prostaglandin E synthase 3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.

PTGES3 Antibodies

PTGES3 for Homo sapiens (Human)

PTGES3 Proteins

PTGES3 Proteins for Homo sapiens (Human)



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